A series of novel quinolinone containing 1,3,5-triazine derivatives have been synthesized, characterized and screened for antimicrobial activity. 7-((4-((3-fluoro-4-morpholinophenyl)amino)-6-(arylamino)-1,3,5-triazin-2-yl)oxy)-3,4-dihydroquinolin-2(1H)-one derivatives were prepared by condensation of 7-((4-chloro-6-((3-fluoro-4-morpholinophenyl)amino)-1,3,5-triazin-2-yl)oxy)-3,4-dihydroquinolin-2(1H)-one with differently substituted aniline derivatives. The designed compounds were confirmed via IR, 1H NMR, Mass spectral data. The synthesized compounds checked for their antimicrobial activity using gram-positive bacteria, gram-negative bacteria and fungi against standard drugs.
Pyrazole derivatives shows remarkable antibacterial activity, antifungal activity, anti-oxidant activity, anti-inflammatory activity, anticancer activity etc. In view of getting to synthesize 2-{4’-[1’,5’-Dimethyl-3’-oxo-2’-phenyl-pyrazol-4’-yl]aminomethyl-1H-1,2,3-triazol-1-yl}-N-arylethanamide derivatives (8a-8j) and 2-[(1’,5’-dimethyl-3’-oxo-2’-phenyl-pyrazol-4’-yl)amino]-N-arylethanamide derivatives (9a-9j). The structures of the compounds were analyzed by IR, 1H NMR, mass spectral data and TLC. The synthesized compounds were evaluated their antimicrobial activity with Gram-positive, Gram-negative bacteria and fungi.
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