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EN
Generally, it is agreed that the meaning of the word has two aspects: the “primary” meaning, i.e. the most specific or direct meaning (called in logic and linguistics “denotation”), and the secondary meaning, i.e. meaning suggested by or associated with a word or thing (“connotation”). Connotations refer also to the cultural and / or emotional associations that become attached to words. However, among the scientists there is no agreement on what aspects of word meaning are included in the connotation. The objective of the paper is to answer the following question: To what extent may associations and emotions be considered as components of word meaning? This paper provides an overview of the analysis of the term “connotation” from the perspective of the twentieth-century’s linguistics. It also attempts to determine the notion of word meaning. Furthermore, it has been demonstrated how to solve the problem of the linguistic description of word meaning.
EN
Formation of a company is usually characterized by excessive formalism and lengthy process, mainly due to inevitable proper control of tailor-made articles of association by public authorities. Lately, several European states have been inspired by the British model of standardized articles of association which may provide for certain benefits. The benefits combine primarily the effect of simplifying and accelerating the process of company formation and the reduction of initial transaction costs. The main aim of this contribution is to analyze various tools of standardized company formation, identify and evaluate advantages and disadvantages of particular national model articles of association and examine the scope of contractual autonomy left to company founders initially (in the setting-up process) or ex post (after the registration of a company). Moreover, model articles of association are analyzed as optional or obligatory tools, and also as a result of autonomous system of mandatory and default rules, which do not need to correspond with the nature of legal regulation (e.g. possibility to transform default rule into mandatory rule within model articles of association). Furthermore, the author introduces possible solutions for the Slovak legal order.
EN
In search for new markers of insulin-dependent diabetics (IDDM) susceptibility we studied the CATT tetranucleotide repeat in intron 1 of tyrosine hydroxylase (TH) gene on chromosome 11p, the CA repeat at T-cell receptor alpha chain (TCRA) locus on chromosome 14q region containing glutamic acid decarboxylase (GAD2) gene.Alleles at these microsatellite loci were indentified in a population of diabetic children and unrelated healthy controlos originationg from Wielkopolska, a midwestern region of Poland.We found significant association of certain alleles at TH, TCRA and D10S211 loci with diabetes in the population under study.On the contrary, none of the alleles at D10S213 locus was associated with the disease.Our findings indicate that typing of microsatellite markers may represent useful additional tool for identifying individuals at high risk of developing IDDM.Regarding loci on chromosome 10 our data and data publishing by other autors may suggest the existence of two separate regions of associatin with IDDM susceptibility on this chromosome.
EN
The existence of different Christian communities is an important aspect of the Church's identity today. People belonging to different religious organizations have an opportunity to strengthen their own faith and the faith in their families. Faith needs to have a 'place' to strengthen itself. The participation in religious community life also helps a believer to answer dificult questions and doubts and experience the beauty of the life among the brethren in faith. The autor focuses on dif erent forms of religious organizations and their role in supporting family life.
EN
The gene encoding solute carrier family 6 member 14 (SLC6A14) has been considered as a candidate gene affecting human obesity. In this study, full-length cDNA (2237 bp) and DNA sequence (24 541 bp) of the porcine SLC6A14 gene were isolated. The porcine SLC6A14 cDNA contains a 5'-untranslated region of 57 bp, a 3'-untranslated region of 254 bp, and an open reading frame of 1926 bp, encoding a deduced protein of 642 amino acids with a molecular mass of 72. 475 kDa and an isoelectric point of 7.82. The genomic structure of the porcine SLC6A14 gene is similar to mammalian orthologs, particularly in terms of exon size and exon/intron boundaries. It comprises 14 exons and 13 introns. A semi-quantitative RT-PCR showed that the porcine SLC6A14 mRNA expression was tissue-specific. Four SLC6A14 single-nucleotide polymorphisms (SNPs) were identified, and 3 informative SNPs were chosen for genotyping in a White Duroc ? Erhualian resource population with phenotype data of growth and fatness traits. The association analysis showed that the c.1438 G>A nonsynonymous polymorphism was associated with birth weight and 21-day body weight (P < 0.05), while g.7944 A>T was associated with 46-day body weight. Linkage and radiation hybrid mapping assigned SLC6A14 to a region around SW1522 on SSCXp13, which did not fall in the confidence interval of the quantitative trait locus (QTL) for growth and fatness traits on SSCX in the resource population. These results indicate that SLC6A14 is not a positional candidate gene for the QTL affecting fatness and growth traits in pigs.
Mesto a dejiny
|
2016
|
tom 5
|
nr 2
82 – 94
EN
In the second half of the 19th century in Hungary there was an enormous increase in the number of associations. While in 1862 there were 579 registered associations, in 1878 it was already 3995. The associations had no duty to keep administration paperwork and agenda. They were acting as independent communes and as a result of this were autonomous written records and administration paperwork. Public authorities had no right to interfere in their own administration records. They just might have consulted them. The way how the written records of each association were kept and preserved for the future generations depended on its individual "conscientious" members. This has resulted in a fact that the researchers who are dealing with the issues of administration record keeping have access mainly to incomplete and fragmentary archive documents. The aim of the article is to present the conditions of the archival historical sources that are related to the research of community life and life in associations in the city of Košice in 1867 – 1914. The research was conducted in archives and libraries located in the investigated city of Košice, as well as in the same type of institutions in Budapest. The available historical sources particularly include the articles of associations, reports to the police headquarters and own documents and records of associations themselves. These include documents such as speeches, annual reports, reports on general meetings, almanacs, journals, publications published by associations and issues of memorial books published on the occasion of special anniversaries to commemorate the founding of association.
EN
The aims of this study were: (1) to find associations of asthma with single-nucleotide polymorphisms (SNPs) within the ADRB2 gene: Arg16Gly, Gln27Glu,-1023 G/A, ?367 T/C,-47 C/T ; (2) to define linkage disequilibrium in the gene region, basing on the analyzed SNPs; and (3) to analyze the importance of ADRB2 polymorphism for response to bronchodilator drugs in children diagnosed with bronchial asthma. We compared 113 asthmatic children and 123 healthy subjects from the Polish population. Genotyping was performed by PCR-RFLP. We found an association of the A allele of ?1023A/G ADRB2 polymorphism with asthma (P = 0.024). No significant associations with other SNPs were detected. Moderate linkage was found between Gln27Glu and -47C/T polymorphisms in linkage disequilibrium analysis (D' = 0.85, r2 = 0.429, LOD = 31.97). No significant differences were found in haplotype frequencies in comparison to the control group, implicating that they are not associated with susceptibility to asthma in the analyzed population. There was no significant correlation between the analyzed SNPs of the ADRB2 gene and the response to beta2-agonists. This is the first report providing suggestive evidence for association of ?1023A/G ADRB2 polymorphism with an increased risk of asthma. The analyzed SNPs may not play a major role in response to beta2-agonists in asthmatic children.
Slavica Slovaca
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2012
|
tom 47
|
nr 1
50 - 62
EN
The author concentrates on associations as an important cognitive source used to examine specific ethno-cultures. The main object of his research consists of mainly Russian mass media in the last two decades. It is the period marked by an intensive search for spiritual values. As it is shown in the paper, it is possible to create a certain hierarchy of the above mentioned values forming a stable part of Russian culture. Associations function as a really important phenomenon of research. Methodological basis for associative research has been created and defined by the team of Prof. Karaulov and is applicable even in our – Slovak or other Slavonic cultures.
9
63%
EN
We have proposed that protein kinase C, an enzyme critical to cell regulation of growth, secretion and differentiation, is a part of a sequence of molecular events that unsderlie learning and memory. Electrophysiological, biochemical and neuro-imaging methods have been employed to show that the enzyme changes its distribution as a result of memory storage within the neural networks that are necessary for the acquisition and performance of various learning tasks in several species. We propose here, a model of protein kinase C as a molecular signal for the association of synaptic input that is parsimonious with the recent data, mainly our laboratory, concerning its function in emory formation.
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