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w słowach kluczowych: 1,2-dimethylhydrazine

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Effect of quercetin on the development of aberrant crypts induced by 1,2-dimethylhydrazine in rat colon

100%

Czeczot H. , Podsiad M. , Skrzycki M.

Acta Poloniae Toxicologica

2001

tom 09

nr 1

Rat colonic lipid peroxidation and antioxidant status: the effects of dietary luteolin on 1,2-dimethylhydrazine challenge

84%

Manju V. , Balasubramaniyan V. , Nalini N.

Cellular and Molecular Biology Letters

2005

tom 10

nr 3

Syphacia muris infection in rats attenuates colorectal carcinogenesis through oxidative stress and gene expression alterations. Implications for modulatory effects by Bryostatin-1

67%

Salim E. I. , Harras S. F. , Abdalla A. G. , Mona M. H.

Acta Parasitologica

2018

tom 63

nr 1

Wplyw zwiazkow alkilujacych na indukcje zaberrowanych krypt w jelicie grubym szczurow rasy Wistar i myszy rasy Swiss

51%

Czeczot H. , Tudek B.

Bromatologia i Chemia Toksykologiczna

1995

tom 28

nr 1

79-86

Badano wpływ związków alkilujących (DMH, MNU, MNNG, MMS) na indukcję zaberrowanych krypt w jelicie grubym samic szczurów rasy Wistar i myszy rasy Swiss w zależności od dawki, drogi podawania i wieku.

The aim of this work was to study the effect of 4 alkylating agents: 1,2-dimethylhydrazine (DMH), N-nitrosomethylurea (MNU); N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and methyl-methane sulphonate (MMS) on the induction of aberrant crypts (AC) in the colon of female Wistar rats and Swiss mice. It was shown that the standard colon carcinogens (DMH and MNU), when administered intragastrically (per os) to the rats and mice, induced aberrant crypts in the dose-dependent manner. It was also found that 9—10 week rats were more sensitive to abberant crypts induction than the younger 3—4 week animals. The aberrant crypts induced by DMH in the colons of 3—4 week female Wistar rats and 3-week female Swiss mice were more frequent in the middle colon and rectum. MNNG and MMS, administrered in our experiment per os and per rectum only to the 3—4 week-old female rats, also induced AC in the colon. The aberrant crypts were evidently more frequent in the animals receiving MNNG per rectum. Among the studied chemicals, MMS induced relatively few aberrant crypts in the colon of the female rats, and only at higher concentrations. The results of our study confirm the hypothesis that aberrant crypts are biomarkers of colonic preneoplastic lesions and demonstrate that the method is useful as a short-term assay for carinogenicity; it may be also used for studying the carcinogenic process in the colon.