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Renesans przeciwciał

100%

Walajtys-Rode E.

2001

nr 3

Uzyskanie przeciwciał monoklonalnych przeciwko związkom izoprenoidowym

51%

Wanke M. , Porebska A. , Walajtys-Rode E.

2001

nr 3

Effect of protein tyrosine kinases on mitochondrial calcium homeostasis in rat hepatocytes treated with thapsigargin

51%

Walajtys-Rode E. , Moehren G. , Hoek J. B.

Cellular and Molecular Biology Letters

1998

tom 03

nr 3

Evaluation of the localization and biological effects of PAMAM G3 dendrimer-biotin/pyridoxal conjugate as HaCaT keratinocyte targeted nanocarrier

45%

Szuster M. , Uram L. S. , Filipowicz-Rachwal A. , Wolowiec S. , Walajtys-Rode E.

Acta Biochimica Polonica

2019

tom 66

nr 2

Activity of cuticle-degrading enzymes from entomopathogenic fungus Conidiobolus coronatus

44%

Czygier M. , Samborski J. , Dzik J. M. , Walajtys-Rode E. , Bogus M.

Wiadomości Parazytologiczne

1998

tom 44

nr 3

Effect of cyclosporin A on immunological response in lungs of guinea pigs infected with Trichinella spiralis

38%

Dzik J. M. , Zielinski Z. , Golos B. , Jagielska E. , Wranicz M. , Walajtys-Rode E.

Acta Biochimica Polonica

2002

tom 49

nr 1

The effects of cyclosporin A (CsA), a potent immunosuppressive drug with antiparasitic activity, on the innate immunological response in guinea pig lungs during an early period (6th and 14th days) after T. spiralis infection were studied. CsA treatment of T. spiralis-infected guinea pigs caused a significant attenuation of immuno- logical response in lungs by decreasing lymphocyte infiltration into pulmonary alveolar space, inhibiting alveolar macrophage superoxide anion production and lowering both the production of NO metabolites measured in bronchoalveolar lavage fluid and expression of the iNOS protein in lung homogenates, allowing us to speculate that the T. spiralis-dependent immunological response is dependent on lymphocyte T function. Interestingly, CsA itself had a pro-inflammatory effect, promoting leucocyte accumulation and macrophage superoxide production in guinea pig lungs. This observation may have a relevance to the situation in patients undergoing CsA therapy. Macrophage expression of the iNOS protein, evaluated by immunoblotting was not influenced by treatment of animals with CsA or anti-TGF-antibody, indicating different regulation of the guinea pig and murine enzymes.