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EFFECT OF REPEATED COLD WATER SWIMMING EXERCISE ON ADAPTIVE CHANGES IN BODY WEIGHT IN OLDER RATS

100%

Bryczkowska I. , Baranowska-Bosiacka I. , Lubkowska A.

Central European Journal of Sport Sciences and Medicine

2017

tom 18

nr 2

77-87

The aim of this study was verification whether an 8-week-long swimming exercise training would induce adaptive changes in body weight in rats and whether possible changes would depend on aquatic environment temperature and animal sex. The exercisetrained groups swam 4 minutes a day, five days a week during eight week of housing. Exercise was performed by swimming in glass tanks containing tap water maintained according to group at 5 ±2°C (cold group) and 36 ±2°C (thermal neutral group). Before and after each week of the experiment, rats were weighed. When comparing the nature of changes in the body weight of rats exposed to swimming exercise training in cold water, attention should be paid to their dependence on sex. There were statistically significant changes in the nature of changes in body weight between male rats and female rats of the cold group (5°C) as early as experimental week 2 until the end of the experiment (p < 0.001). Interestingly, the females exposed to swimming exercise training at 5°C were the only group in which an increase in body weight occurred during experimental week 8 in relation to baseline values.

The effect of new non-cross resistant antitumour agents on the energy state of human erythrocytes

75%

Nowak R. , Baranowska-Bosiacka I. , Stefańska B. , Machaliński B. , Hłyńczak A. J. , Tarasiuk J.

Acta Biochimica Polonica

2005

tom 52

nr 4

953-957

Multidrug resistance (MDR) of tumour cells is related to the overexpression of ATP-dependent pumps responsible for the active efflux of antitumour agents out of resistant cells. Benzoperimidine and anthrapyridone compounds exhibit comparable cytotoxic activity against sensitive and MDR tumour cells. They diffuse extremely rapidly across the plasma membrane and render the ATP-dependent efflux inefficient. Such uptake could disturb an energy metabolism of normal cells possessing an elevated level of ATP-dependent proteins, especially erythrocytes having a high level of the MRP1, MRP4 and MRP5 proteins. In this study the effect of five antitumour agents: benzoperimidine (BP1), anthrapyridones (CO1, CO7) and reference drugs used in the clinic: doxorubicin (DOX) and pirarubicin (PIRA), on the energetic state in human erythrocytes has been examined. These compounds have various types of structure and kinetics of cellular uptake (slow - DOX, CO7, moderate - PIRA, fast - BP1, CO1) resulting in their different ability to saturate ATP-dependent transporters. The energetic state of erythrocytes was examined by determination of purine nucleotide contents (ATP, ADP, AMP), NAD+ and values of adenylate energy charge (AEC) using an HPLC method. It was found that the level of nucleotides as well as the AEC value of erythrocytes were not changed during 24 h of incubation with these agents independently of their structure and ability to saturate ATP-dependent pumps. This is a very promising result in view of their potential use in the clinic as antitumour drugs against multidrug resistant cancers.