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EN
Catalytic decompostion and reduction of NOx by NH3 and CO in the presence of MFI zeolites and MFI zeolite containing catalysts was investigated. The catalyst activity was studied as a function of zeolite ion exchanged form (Na, H, Cu forms), type of an element introduced into zeolite framework, process temperature. Isomorphous substituted Fe, Co, Mn and mixed forms of these elements were used. Three types of catalysts were tested: a) pure zeolites, b) zeolites deposited on a-Al2O3 or cordierite, c) zeolite extrudates with g-Al2O3. [Fe]-MFI crystallized on a-Al2O3 used in the reduction of NOx by CO was the best catalyst. In the process of catalytic reduction of NOx by NH3 the best results were obtained in the presence of Na-[Fe]-MFI molecular sieve. In the process of NOx decomposition, the highest conversion values were obtained in the presence of Cu-[Al]-MFI and [Fe]-MFI.
EN
The effects of cyclosporin A (CsA), a potent immunosuppressive drug with anti­parasitic activity, on the innate immunological response in guinea pig lungs during an early period (6th and 14th days) after T. spiralis infection were studied. CsA treat­ment of T. spiralis-infected guinea pigs caused a significant attenuation of immuno- logical response in lungs by decreasing lymphocyte infiltration into pulmonary alveo­lar space, inhibiting alveolar macrophage superoxide anion production and lowering both the production of NO metabolites measured in bronchoalveolar lavage fluid and expression of the iNOS protein in lung homogenates, allowing us to speculate that the T. spiralis-dependent immunological response is dependent on lymphocyte T func­tion. Interestingly, CsA itself had a pro-inflammatory effect, promoting leucocyte ac­cumulation and macrophage superoxide production in guinea pig lungs. This observa­tion may have a relevance to the situation in patients undergoing CsA therapy. Macrophage expression of the iNOS protein, evaluated by immunoblotting was not in­fluenced by treatment of animals with CsA or anti-TGF-antibody, indicating different regulation of the guinea pig and murine enzymes.
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