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1 Polish Journal of Chemistry

1 2006

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Synthesis and In Vitro Cytotoxic Activity of Novel 6-Chloro-1,1-dioxo-1,4,2-benzodithiazin-3-ylhydrazine Derivatives

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Pomarancka E. , Bednarski P. , Grunert R. , Brzozowski Z. , Lach J.

2006

tom Vol. 80, nr 3

429-438

The syntheses of 1-(6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-yl)-4-hydroxysemicarbazides 11-19, hydroxybenzaldehyde N-(6-chloro-7-methyl-1,1-dioxo-1,4,2- benzodithiazin-3-yl)hydrazones 21-24 and 8-chloro-2-(1-naphthylamino)-5,5- dioxo[1,2,4]triazolo[2,3-b][1,4,2]benzodithiazine-7-carbonitrile (26) are described. All compounds were tested for their in vitro cytotoxic potency against 12 human cancer cell lines at the Institute of Pharmacy, University of Greifswald. The compounds 11-19 were inactive, whereas 22 and 24 exhibited weak tumor growth inhibitory properties. The compound 26 was screened at the National Cancer Institute and showed reasonable anticancer activity.