Wyniki wyszukiwania - Biblioteka Nauki

1

Effect of malathion on the initiation and elongation steps of transcription

100%

Walter Z. , Wiszkowska H.

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1990

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tom 37

|

nr 1

2

Zagadnienie ciągłości łańcucha polidezoksyrybofosforanowego w DNA eukariotów

100%

Olinski R. , Walter Z.

|

nr 4

3

Chromium induces DNA-protein cross-linking in isolated lymphocytes

100%

Walter Z. , Wozniak K.

|

tom 40

4

Interstrand DNA-platinum-DNA/cross-links induced by cis- and trans-diamminedichloroplatinum (II) at elevated temperature

80%

Kulamowicz I. , Walter Z. , Krupa R.

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1990

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tom 37

|

nr 1

5

Characterization of three subclasses of DNA-dependent RNA polymerases C from calf thymus

80%

Budzynska K. , Zbikowski W. , Walter Z.

|

nr 1-2

6

Estimation of the extent of platination and the sites of Pt binding after interaction of cis- and trans-diamminedichloroplatinum(II) whit DNA and chromatin

80%

Olinski R. , Wiaderkiewicz R. , Walter Z.

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1985

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tom 32

|

nr 2

7

The effect of zinc ions on trenscription in eucariotic system

80%

Kubiak A. , Brudzyńska K. , Walter Z. , University of Łódź I. o. B. a. B.

|

tom 5

8

Thermal stability of DNA as affected by the organophosphorus insecticide Dichlorvos

80%

Blasiak J. , Kleinwachter V. , Walter Z. , Zaludova R.

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nr 2

EN

The interaction of the commonly used organophosphorus insecticide dichlorvos (2,2-dichlorovinyl dimethyl phosphate) with synthetic and mammalian DNA was investigated by spectroscopic techniques. Two kinds of DNA were employed: calf thymus DNA (CT DNA) and synthetic two-stranded oligomer of sequence 5' - d(TTGGATCCGAATTCAAGCTT)-3' Melting curves and circular dichroism spectra were taken for the DNAs in the presence of the insecticide at a dichlorvos/DNA molar ratio of 0.5. The insecticide evoked a decrease of the melting temperature and a broadening of the transition range for CT DNA. Similar effects were observed for the synthetic oligomer but they were much less pronounced than in the case of CT DNA. Dichlorvos did not evoke significant changes in the circular dichroism spectra of both DNAs. Obtained results indicate that dichlorvos perturbs the thermal stability of DNA, which is evidence that the insecticide has the ability to interact directly with DNA. Because dichlorvos is primarily neurotoxic, evidence of non-specific effect could be important for assessing the environmental risk connected with its use.

9

Plasmid as a model system for studying DNA damage

80%

Blasiak J. , Kowalik J. , Walter Z.

|

tom 40

10

Platinum-induced changes in F0F1 ATPase activity in mitochondria

80%

Walter Z. , Grabowska M. , Majsterek I.

|

tom 44

11

Cross-linking of nuclear proteins to DNA by platinum compounds

80%

Walter Z. , Wozniak K. , Kowalik J.

Cellular and Molecular Biology Letters

|

1997

|

tom 02

|

nr 4

EN

In this work we investigated the lymphocyte nuclear proteins which participated in DNA-protein cross-links induced by three platinum compounds: cis-DDP, trans-DDP and carboplatin. Our studies indicated that many proteins were cross- linked to DNA in the intact cell. Trans-DDP was the most effective cross-linker. The cross-linking process depended on time of the cells incubation with aforementioned compounds. Carboplatin produced the DNA-protein cross-links more slowly and less effectively than cis-DDP. After incubation of the cells with cis-DDP, trans- DDP and carboplatin a similar protein pattern was obtained. In case of all compounds studied 34.5 kDa protein was abundantly represented.

12

Binding of the anticancer drug cis-diamminedichloroplatinum [II] to mammalian mitochondrial DNA

80%

Walter Z. , Grabowska M. , Majsterek I.

|

tom 40

13

The detection and characterization of rat protein recognizing DNA damaged by N-acetoxy-acetylaminofluorene

71%

Pietrowska M. , Lanuszewska J. , Walter Z. , Rzeszowska-Wolny J. , Widlak P.

|

tom 05

|

nr 4

423-431

EN

Proteins recognizing DNA damaged by the chemical carcinogen N- acetoxy-acetylaminofluorene (AAAF) were analyzed in nuclear extracts from rat tissues, using a 36 bp oligonucleotide as the substrate and an electrophoretic mobility shift assay. Two major proteins that form complexes with DNA damaged by AAAF were detected; one of them also bound DNA damaged by cis-diammine-dichloroplatinum. The complex specific for AAAF-damaged DNA contained protein loosely attached to nuclear components. It was extracted with 0.1 M NaCl. The amount of this protein was estimated at about 105 copies per liver cell nucleus, and its probable size was about 42 kDa as detected by the Southwestern blotting assay. Its affinity for DNA damaged by AAAF was ~10-fold higher than that for undamaged DNA. Analogous AAAF- DDB (damaged-DNA-binding) proteins were also detected in extracts from rat brain, testis and kidney tissue. The levels of such proteins were not affected in rats treated with the carcinogen 2-acetylaminofluorene.

14

The quantitative PCR technique resolves ambiguities concerning a small rearrangement of human chromosome 6q12-13

70%

Nowacka J. , Helszer Z. , Walter Z. , Plucienniczak A. , Kaluzewski B.

|

tom 42

|

nr 4

15

Mitochondrial glutathione-S-transferases from pig thymus and the effect of organophosphate insecticides on their activity

61%

Walter Z. , Wojtysiak-Staniaszczyk M. , Przepiorkiewicz M. , Kargas C. , Gawronska M. , Grabowska M. , Majsterek I.

Acta Biologica Cracoviensia. Series Zoologia

|

2001

|

tom 43

16

Apoptotic effect of cyanobacterial hepatotoxic extracts from Polish reservoirs

61%

Mankiewicz J. , Walter Z. , Tarczynska M. , Zalewski M. , Fladmark K. E. , Doskeland S. O.

|

tom 05

|

nr 2