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1
Content available remote Effect of some glycolytic intermediates and palmitoyl-CoA on α-glycerophosphate dehydrogenase in mitochondria isolated from liver of triiodothyronine-treated rats
100%
Świerczyński J. , Ścisłowski P. , Aleksandrowicz Z.
Acta Biochimica Polonica
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1977
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tom 24
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nr 4
281-287
2
Content available remote Carboxylation of pyruvate via extramitochondrial malic enzyme in rat skeletal muscle
100%
Świerczyński J. , Aleksandrowicz Z. , Żelewski L.
Acta Biochimica Polonica
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1986
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tom 33
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nr 1
47-54
3
Content available remote Serum Cystatin C in Relation to Fat Mass Loss After Bariatric Surgery"
88%
Śledziński T. , Proczko-Markuszewska M. , Kaska Ł. , Stefaniak T. , Świerczyński J.
Polish Journal of Surgery
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2012
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tom 84
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nr 4
202-207
EN
Serum cystatin C concentration, generally accepted as renal function marker, is associated with cardiovascular risk and metabolic syndrome. Recent studies indicate that cystatin C increases in human obesity and that adipose tissue contributes to enhanced serum cystatin C concentration in obese subjects.The aim of the study was to assess whether a reduction in body and fat mass after bariatric surgery has any impact on serum cystatin C concentrations.Material and methods. Serum from 27 obese patients were tested before and 6 months after bariatric surgery. Twenty healthy subjects with normal body weight served as controls. Serum cystatin C concentrations were assayed by ELISA.Results. Serum cystatin C concentrations were significantly higher in obese patients compared with non-obese subjects. Decrease of body and fat mass after bariatric surgery resulted in improvement of several parameters associated with cardiovascular risk and metabolic syndrome, like serum lipids, blood pressure and insulin sensitivity. Surprisingly the mean postoperative serum cystatin C concentration was not significantly different from that before surgery. Serum creatinine and GFR also remained unchanged.Conclusion. The results presented here suggest that serum cystatin C concentration is not tightly associated with body and fat mass loss in obese patients after bariatric surgery.
4
Content available remote Human Serum Paraoxonase Activity Decreases After Vertical Banded Gastroplasty*
75%
Goyke B. , Goyke E. , Śledziński T. , Adrych K. , Raczyńska S. , Śledziński Z. , Świerczyński J.
Polish Journal of Surgery
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2007
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tom 79
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nr 6
436-444
EN
The aim of the study. Investigation of the effect of vertical banded gastroplasty (VBG), which is an effective method of treating patients with morbid obesity on serum paraoxonase (PON) activity.Material and methods. Serum PON activity was measured in twenty eight morbidly obese patients 6 and 12 months after surgery. PON activity was also measured in the serum and liver of rats maintained on a restricted diet for one month.Results. We found that VBG-induced significant reduction in body weight and serum PON activity at 6 and 12 months after surgery. Similar patterns of decreases in serum paraoxonase activity in obese patients after VBG were observed in A, AB and B paraoxonase/esterase phenotypes. After VBG, several clinically relevant events occurred: a) a decrease of serum triacylglycerol concentration was observed; b) no significant changes in total serum cholesterol and LDL-cholesterol concentrations were found; c) serum HDL-cholesterol concentration increased slightly.Paraoxonase activity in the serum of rats maintained on a restricted diet, which induced approximately 30% and 50% of rat body weight and fat mass loss, respectively, was lower than in control animals.Conclusions. This study indicates that after VBG significant decreases in serum paraoxonase activity occur in obese subjects. It is likely that less food ingestion and possibly a different type of food consumed by the obese subjects after VBG (compared to type of food consumed before surgery) may contribute to decreases in serum PON activity.
5
Content available remote Changes of nucleotide content in human and rat heart during cardiac surgery and ischemia
75%
Smoleński R. T. , Skladanowski A. C. , Świerczyński J. , Perko M. , Narkiewicz M. , Żydowo M. M.
Acta Biochimica Polonica
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1993
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tom 40
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nr 4
531-538
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