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2 Wiadomości Parazytologiczne

2 2001

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The significance of the level of antibodies in the evaluation of the effects of treatment of toxocariasis

100%

Malafiej E. , Spiewak E.

nr 4

The observation of a group of 168 children treated for toxocariasis shows that the most frequent symptoms at the time of the physical examination were abdominal pains - 41 %; headache was observed in 12% cases. Eosinophilia was found in 9.2% cases. The final diagnosis was based on the results of serological investigation. The level of IgG antibodies was established by the ELISA method using the excretory - secretory antigen of Toxocara canis larvae. A few years of studies lead to the observation that after treatment the return of the level of antibodies to normal is a very slow process - positive results are found in 57% of patients even after 4 to 7 years and the decrease of the mean titre of antibodics does not exceed 45%. The observations show that examination of the level of antibodies in the way hitherto applied does not provide a satisfactory indication of the positive effect of treatment. Therefore, it is necessary to develop a system of additional laboratory tests that will altow a faster evaluation of the effects of treatment of this disease.

Serological investigation in children infected with Ascaris lumbricoides

100%

Malafiej E. , Spiewak E.

nr 4

The study included 260 hospitalised children with suspected infection with human ascaris. In serological diagnostics a protein antigen obtained from Ascaris lumbricoides was used. ELISA method was applied. IgG antibodies were detected. Positive results were found in 15% of the examined children. No relation to the gender or demographic conditions was found. The most frequently observed symptoms in the patients with Ascaris lumbricoides were: abdominal pain - 87%. diarrhoea 15%. In 31% of the cases eosinophilia was found. Scatoscopy was carried out for all the patients, using the PARASEPT system and Kato and Miura methods as well as decantation and tlotation. The examination. which was repeated three times, did not show cysts or eggs. Serological investigation exhibits higher sensitivity than the traditional methods. Their use in recognising ascariasis in humans significantly facilitates diagnostic procedures, especially in the lung phase of the disease, the larval stage or in cases of infection with an individual parasite, when the faeces samples do not contain the eggs. Serological investigation is also useful in all cases of suspected VLM.