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1 Acta Neurobiologiae Experimentalis

1 2009

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Colocalisation of glucocorticoid and 5-HT1A receptor immunoreakrivity-expressing cells in the brain structures of low and high anxiety rats

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Lebner M. , Taracha E. , Maciejak P. , Szyndler J. , Skorzewska A. , Turzynska D. , Sobolewska A. , Wiskowska-Stanek A. , Hamed A. , Bidzinski A. , Plaznik A.

Acta Neurobiologiae Experimentalis

2009

tom 69

nr 3

In recent years we have elaborated an animal model to examine the neurochemical background of differences in the individual responses to conditioned aversive stimuli, using the strength of a rat contextual fear test, as a discriminating variable: low responders (LR), i.e. rats with duration of a freezing response one standard error, or more, below the mean value and high responders (HR), i.e. rats with duration of a freezing response one standard error, or more, above the mean value. It was found that 1.5 h after a testing session of contextual fear test, the LR animals showed a higher density of 5-HT1A and glucocorticoid immunoreactivity-expressing cells (GRsir) in the cortical M2 area and hippocampal dentate gyrus as well as an increased number co-expressing 5-HT1A /GRs-ir in the same areas. The HR rats had a signifi cantly higher concentration of 5-HT1A and GRs-ir in the basolateral amygdala. The present data add more arguments for the neurobiological background of differences in individual responses to aversive conditioned stimuli.