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In vitro study on the influence of S9 fraction on genotoxicity of hydralazine and dihydralazine

100%

Chlopkiewicz B.

Folia Histochemica et Cytobiologica. Supplement

1997

tom 35

nr 2

Studies on the mechanism of mutagenicity and genotoxicity induced by dihydralazine

51%

Chlopkiewicz B. , Ejchart A. , Marczewska J.

Acta Biochimica Polonica

1995

tom 42

nr 3

Dihydralazine was found to be mutagenic towards S. typhimurium TA1537, TA97, TA1538 and TA98 and genotoxic towards E. coli PQ37. Using the nitro blue tetrazolium reduction method we have found that dihydralazine can generate active oxygen species. The possible role of active oxygen species in mutagenicity (Ames test) and genotoxicity (SOS Chromotest) of dihydralazine was studied by testing the influence of the different active oxygen species scavengers on these two processes. Of the active oxygen scavengers tested, only superoxide dismutase suppressed partially the mutagenic and genotoxic activity of dihydralazine. This result seems to indicate that superoxide anion play a role in these two biological events.

Evaluation of the SOS chromotest for detection of genotoxic drugs

51%

Marczewska J. , Chlopkiewicz B. , Ejchart A. , Koziorowska J.

Acta Microbiologica Polonica

1993

tom 42

nr 2

Contribution of N-oxidation and OH radicals to mutagenesis of 2-chloropyridine in Salmonella typhimurium

44%

Chlopkiewicz B. , Wojtowicz M. , Marczewska J. , Prokopczyk D. , Koziorowska J.

Acta Biochimica Polonica

1993

tom 40

nr 1