Many neurons of the vertebrate and invertebrate central nervous system (CNS) exhibit rhythmic oscillations of membrane potentials in absence of external stimuli. Spontaneous firing of these cells generates the activity in various areas of CNS. Firing patterns produced by autoactive neurons and role of several ionic conductances in driving membrane potential to the threshold of action potential generation is described.
Natural neurotoxins are promising molecules in the actual search for the development of alternative pest management since chemical insecticides pose unacceptable risks to the environment and to health. The aim of the article is to describe the application of two electrophysiological methods (double-oil-gap technique used on cockroach isolated giant axon and microelectrode technique used on cockroach neurosecretory DUM cells in situ) to study neurotoxin effects on insect nervous system function.
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