Wyniki wyszukiwania - Biblioteka Nauki

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Effect of 28-day exposure to fenpropathrin on the activities of serum alanine transaminase and liver antioxidant enzymes in mice

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Nieradko-Iwanicka B. , Borzecki A.

Bulletin of the Veterinary Institute in Puławy

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2015

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tom 59

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nr 1

EN

Fenpropathrin (FEN) was administered intraperitoneally in doses of 2.38 mg/kg, 5.9 5mg/kg, or 11.9 mg/kg b.w. to mice for 28 consecutive days. FEN did not significantly affect the activity of alanine transaminase (ALT) in the sera. Superoxide dismutase and glutathione peroxidase activities were significantly elevated in the liver after a 28-d exposure to moderate or highest doses of the pesticide. These results demonstrate that the 28-day exposure to FEN leads to an up-regulation of expression of antioxidant enzymes in response to an oxidative stress in mouse liver without causing a significant increase in ALT activity.

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How deltamethrin produces oxidative stress in liver and kidney

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Nieradko-Iwanicka B. , Borzecki A.

Polish Journal of Environmental Studies

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2016

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tom 25

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nr 3

EN

Deltamethrin (DEL) is a synthetic pyrethroid widely used as an insecticide. The aim of our study was to determine the effect of a single exposure of female albino Swiss mice to DEL (at doses of 8.3 mg/kg, 20.75 mg/kg, or 41.5 mg/kg) on parameters of liver and kidney function and activities of antioxidant enzymes in these organs. The activity of alanine transaminase (ALT) in the blood sera of the experimental animals was not significantly elevated after exposure to DEL. Asparagine transaminase (AST) activity was signifi cantly higher in the groups exposed to the moderate and the highest dose of DEL. The levels of creatinine in the blood sera of the experimental animals did not significantly differ among the groups. The activities of superoxide dismuthase (SOD) and glutathione peroxidase (GPx) were significantly reduced in the livers of mice exposed to the highest dose of DEL in comparison with controls. In the kidneys, however, the SOD and GPx activities were significantly elevated after exposure to the highest dose of DEL. In conclusion, DEL produces oxidative stress in the livers and, to a lesser degree, the kidneys of exposed animals.

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Effect of bifenthrin on memory processes, movement activity, and coordination in mice exposed to transient cerebral oligaemia

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Nieradko-Iwanicka B. , Borzecki A.

Bulletin of the Veterinary Institute in Puławy

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2008

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tom 52

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nr 2

EN

The purpose of the present study was to examine whether the effects of exposure to 0.1LD₅₀ of bifenthrin on memory processes, movement activity, and coordination could be exacerbated by transient reduction of cerebral oxygen supply. The transient occlusion of both common carotid arteries (BCCA) in adult mice was performed under anaesthesia. Intraperitoneal LD₅₀ for bifethrin was estimated to be 16.1mg/kg b.w. The memory retention was evaluated in a step-through passive avoidance task (PA), working spatial memory in a Y-maze, movement coordination on a rota-rod, and movement activity in an automated device. Long-term memory impairment caused by bifenthrin was exacerbated by BCCA. Movement co-ordination was significantly altered in animals treated with the compound. Movement activity was slightly decreased in animals after BCCA and pesticide injection. These results indicate that cerebral oligaemic hypoxia potentiates long-term memory impairing effect of bifenthrin.

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Influence of subtoxic doses of fenitrothion on memory processes, movement activity, and movement coordination in mice exposed to transient oligaemic brain hypoxia

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Nieradko-Iwanicka B. , Borzecki A.

Bulletin of the Veterinary Institute in Puławy

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2008

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tom 52

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nr 2

EN

The aim of the study was to find out if subtoxic doses of fenitrothion (0.1 LD₅₀, LD₅₀ =166.6 mg/kg) administered to mice exposed to transient oligaemic brain hypoxia induced by bilateral clamping of the carotid arteries (BCCA) influence memory processes, movement activity, and coordination. The BCCA was carried out under ketamine + xylazine anaesthesia. Common carotid arteries were clamped for 30 min. Twenty-four hours later; the animals were injected intraperitoneally with 0.1 LD₅₀ of fenitrothion. Controls and sham-operated animals (with carotids separated but not clamped) were injected with respective volumes of bidistilled water. All the animals were trained in passive avoidance (PA) task. The examination of memory retention in PA was done 24 h later followed by testing of fresh spatial memory in a Y- maze, movement co-ordination, and spontaneous movement activity in a 30-min period. Fenitrothion did not significantly alter memory processes in the examined mice. However, the movement coordination was significantly impaired in animals that underwent BCCA alone as well as being oligaemic and under the influence of fenitrothion vs control groups. The same groups demonstrated significantly impaired spontaneous movement activity vs controls.

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