Wyniki wyszukiwania - Biblioteka Nauki

1

Effects of different doses of tilmicosin on erythrocyte catalase activity and plasma malondialdehyde levels in chicks

100%

Eraslan G.

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tom 51

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nr 1

EN

Three-day-old 105 Ross race female broiler chicks were used. The chickens were divided into 5 groups comprising 1 control and 4 experimental groups. Animals in the control group (group 1) were provided with normal drinking water, whereas the experimental groups, namely, group 2, group 3, group 4 and group 5 were administered with tilmicosin at doses of 20 ppm, 40 ppm, 80 ppm and 160 ppm (approximately, 5 mg/kg/b.w./d, 10 mg/kg/b.w./d, 20 mg/kg/b.w./d, and 40 mg/kg/b.w./d), respectively, via drinking water for a period of 3 d. Seven animals were euthanized from each group, on the 1st d (first period), 4th d (second period) and 7th d (third period) of the experiment for the assessment of blood malondialdehyde (MDA) levels and catalase (CAT) activity. Statistically significant differences in comparison with the control group were observed in plasma MDA levels of all experimental groups in the first period, groups 2 and 5 in the second period, and group 4 in the third period. With regards to CAT activity, a statistically significant decrease was found in all experimental groups only in the first period.

2

Ocular pharmacokinetics of enrofloxacin in dogs

51%

Essiz D. , Eraslan G. , Kibar M.

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tom 51

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nr 4

3

Changes in malondialdehyde level and catalase activity and effect of toltrazuril on these parameters in chicks infected with Eimeria tenella

51%

Eraslan G. , Cam Y. , Eren M. , Liman B. C.

Bulletin of the Veterinary Institute in Puławy

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2004

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tom 48

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nr 3

4

Efficacy of N-acetylcysteine on aflatoxicosis in rabbits

38%

Cam Y. , Eraslan G. , Atasever A. , Eren M. , Liman B. C. , Seybek N.

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2008

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tom 17

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nr 2

189-197

EN

The aim of this study was to determine the clinical, hematological, biochemical and pathological findings, and to evaluate the efficiency of n-acetylcysteine (NAC) in experimentally induced aflatoxicosis in rabbits. Our study divided 42 rabbits into 6 groups. The groups received the following treatment: Group 1: control group without treatment, Group 2: aflatoxin (AF) (0.4 mg/kg body weight (bw)), Group 3: AF (0.4 mg/kg bw) plus NAC (250 mg/kg bw), Group 4: AF (0.4 mg/kg bw) plus NAC (500 mg/kg bw), Group 5: NAC (250 mg/kg bw), Group 6: NAC (500 mg/kg bw). N-acetylcysteine was administered intramuscularly on day 1 following the administration of AF for 5 days. At the beginning of the study and on days 1, 4 and 7 following the administration of AF, blood samples were collected for haematological and biochemical analysis. Necropsy and histopathological examination were performed. Clinical signs were observed starting from day 1 following the administration of AF. The signs of toxicosis included decreased feed and water consumption, dullness, dehydration, emaciation and convulsion. Four rabbits died in Group 2 and 2 rabbits died in Groups 3 and 4 treated with NAC. During the study, white blood cell (WBC) counts, mean platelet volume (MPV), mean corpuscular volume (MCV) and red blood cell distribution width (RDW) values, serum urea levels and aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transpeptidase (GGT) activities increased whereas red blood cell (RBC) and platelet counts, hemoglobin (Hgb) and hematocrit (Hct) values, total protein, total cholesterol, triglyceride and glucose levels decreased for Group 2 given only AF compared with controls. These parameters approximated to control levels for Groups 3 and 4 after the treatment with NAC. Histopathological examination showed that the main affected organ was liver. Lipid degeneration, destruction and fibrosis in the liver were detected for Group 2. Histopathological changes in the liver were observed to be less severe for Groups 3 and 4. The study demonstrated that administration of NAC might be useful for the treatment of aflatoxicosis in rabbits.

5

Comparative pharmacokinetics of various sulfadoxine-trimethoprim preparations used on dogs in veterinary medicine

38%

Eraslan G. , Kanbur M. , Liman B. , Cam Y. , Atalay O. , Altinordulu S.

Medycyna Weterynaryjna

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2009

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tom 65

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nr 07

EN

Twenty-eight mix-breed male dogs of approximately 3 years of age and with similar body weights were used in the study. Four groups, each including 7 animals, were established. The animals included in the first, second, third, and fourth groups were administered formulations A, B, C, and D, respectively, containing 200 mg sulfadoxine and 40 mg trimethoprim per millilitre, at a dose of 25 mg/kg body weight sulfadoxine by intramuscular route at the same site of the body. Subsequently, blood samples were collected at 0.083, 0.25, 0.50, 1.0, 1.5, 2.0, 4.0, 6.0, 12 and 24 hours. The levels of sulfadoxine-trimethoprim in the plasma samples were measured by means of a HPLC device. Pharmacokinetic calculations were performed in compliance with the two-compartment open model. According to statistical analyses, amongst the parameters evaluated, significant differences were determined to exist between the groups only with respect to the mathematical coefficients (A₂*), hybrid rate constant for terminal elimination phase (β), half life at α phase (t½α), half life at β phase (t½β) and mean residence time (MRT) values for sulfadoxine, and with respect to the A₁*, first order absorption rate constant (kₐ), β and MRT values for trimethoprim (p < 0.05).

6

Effects of dietary aflatoxin and sodium bentonite on some hormones in broiler chickens

38%

Eraslan G. , Essiz D. , Akdogan M. , Sahindokuyucu F. , Altintas L. , Hismiogullari S. E.

Bulletin of the Veterinary Institute in Puławy

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2005

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tom 49

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nr 1

7

Evaluation of aflatoxin toxicity in Japanese quails given various doses of hydrated sodium calcium aluminosilicate

38%

Eraslan G. , Liman B. C. , Guclu B. K. , Atasever A. , Koc A. N. , Beyaz L.

Bulletin of the Veterinary Institute in Puławy

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2004

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tom 48

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nr 4

8

Efficacy of dietary sodium bentonite against subchronic exposure to dietary aflatoxin in broilers

38%

Eraslan G. , Essiz D. , Akdogan M. , Karaoz E. , Oncu M. , Ozyildiz Z.

Bulletin of the Veterinary Institute in Puławy

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2006

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tom 50

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nr 1

9

Aspects of using N-acetylcysteine in aflatoxicosis and its evaluation regarding some lipid peroxidation parameters in rabbits

38%

Eraslan G. , Cam Y. , Eren M. , Liman B. C. , Atalay O. , Seybek N.

Bulletin of the Veterinary Institute in Puławy

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2005

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tom 49

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nr 2