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A focus on homocysteine in autism

100%

Kaluzna-Czaplinska J. , Zurawicz E. , Michalska M. , Rynkowski J.

Acta Biochimica Polonica

2013

tom 60

nr 2

Homocysteine is an amino acid, which plays several important roles in human physiology. A wide range of disorders, including neuropsychiatric disorders and autism, are associated with increased homocysteine levels in biological fluids. Various B vitamins: B6 (pyridoxine), B12 (cobalamin), and B9 (folic acid) are required as co-factors by the enzymes involved in homocysteine metabolism. Therefore, monitoring of homocysteine levels in body fluids of autistic children can provide information on genetic and physiological diseases, improper lifestyle (including dietary habits), as well as a variety of pathological conditions. This review presents information on homocysteine metabolism, determination of homocysteine in biological fluids, and shows abnormalities in the levels of homocysteine in the body fluids of autistic children.

Homocysteine level in urine of autistic and healthy children

100%

Kaluzna-Czaplinska J. , Michalska M. , Rynkowski J.

Acta Biochimica Polonica

2011

tom 58

nr 1

Homocysteine is an amino acid which plays several important roles in human physiology and is an important biomarker for possible deficiencies of various vitamins (vitamin B6 and B12, folic acid). In this work GC-MS method was used to determine the levels of homocysteine in the urine of autistic and healthy children. The levels of homocysteine in urine samples from 34 autistic and 21 healthy children were 2.36 ± 1.24 and 0.76 ± 0.31 (mmol∙mol-1 creatinine), respectively. The higher level of homocysteine in autistic children may indicate deficiencies of folic acid and vitamins B6 and B12 in nutrition of these children. The results of this work were taken into consideration in the nutrition of autistic children treated in the Navicula Centre of Diagnosis and Therapy of Autism in Łódź (Poland).

Pre- and postnatal exposure of children to tobacco smoke during the first four years of life-observations of the authors

63%

Kamer B. , Pasowska R. , Grys W. , Socha-Banasiak A. , Kamer-Bartosinska A. , Matczak-Rynkowska A. , Kaluzna-Czaplinska J. , Rynkowski J.

Annals of Agricultural and Environmental Medicine

2014

tom 21

nr 4