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Introduction and aim. Primary musculocutaneous lymphoma is extremely rare and associated with poor prognosis. Here, we present a case of refractory primary muscular lymphoma with overlying cutaneous involvement with the aid of 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG PET/CT) for staging and treatment. Description of the case. We present the case of a 52-year-old man presented with musculocutaneous Hodgkin’s lymphoma having swelling and discolored areas over the left leg and right arm associated with itchiness. Upon examination, there was scaling, erythema over the body with Gottron’s papules on knuckles and heliotrope rash. Skin and muscle biopsy were suggestive of Hodgkin’s lymphoma. This patient was had primary musculocutaneous lymphoma. His diagnosis was delayed. PET/CT was performed for staging and response to treatment, which was suggestive of refractory disease. Conclusion. PET/CT plays a vital role in diagnosis, staging, response to therapy and helps in optimized treatment for these specific patients.
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