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Angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor blockers affect kynurenic acid production in rat brain cortex in vitro

100%

Zakrocka I. , Targowska-Duda K. M. , Wnorowski A. , Kocki T. , Jozwiak K. , Turski W. A.

Acta Neurobiologiae Experimentalis

2017

tom 77

nr Suppl.1

INTRODUCTION: Angiotensin converting enzyme inhibitors (ACE-Is) and angiotensin II type 1 receptor blockers (ARBs) possess antihypertensive and neuroprotective properties. Kynurenic acid (KYNA), a broad spectrum glutamate antagonist is produced from L-kynurenine by kynurenine aminotransferases (KAT), mainly by KAT I and KAT II isoforms. AIM(S): The goal of our study was to analyze the effect of ACE-Is and ARBs on KYNA synthesis and KATs activity in rat brain cortex in vitro. METHOD(S): The influence of ACE‑Is (lisinopril, perindopril and ramipril) and ARBs (irbesartan, losartan, telmisartan) on KYNA production and KATs activity was examined. Slices and homogenates of rat brain cortex were incubated for 2 hours in the presence of L-kynurenine and examined ACE-I or ARB. KYNA was separated by HPLC and quantified fluorometrically. Moreover, the molecular docking of ARBs to KAT II and the analysis of KAT II coding genes expression in human and rat cerebral cortex were performed. RESULTS: ACE‑Is differently influenced KYNA synthesis and KATs activity in rat brain cortex in vitro. All examined ARBs decreased KYNA production and both KAT I and KAT II activity in rat brain cortex in vitro. Molecular docking showed that analyzed ARBs can bind to an active site of KAT II. CONCLUSIONS: Our study indicates that ACE-Is and ARBs may change KYNA production in rat brain cortex in vitro. ARBs inhibitory effect on KATs activity and KYNA synthesis suggest that ARBs may have beneficial effect in schizophrenia or dementia. FINANCIAL SUPPORT: This study was supported by National Science Centre (NCN) grant PRELUDIUM 4, No UMO-2012/07/N/NZ4/02088.

Level of vitamin 25 (OH) D and B group vitamins and functional efficiency among the chronically ill elderly in domiciliary care - a pilot study

100%

Kocka K. H. , Slusarska B. J. , Nowicki G. J. , Bartoszek A. B. , Rudnicka-Drozak E. A. , Panasiuk L. , Kocki T.

Annals of Agricultural and Environmental Medicine

2019

tom 26

nr 3

Surgical resection of lung cancer inhibits mRNA expression of GOT2 gene encoding kynurenine aminotransferase in leukocytes

100%

Prystupa T. K. , Sagan D. , Kocki J. , Kocki T. , Szymanowski R. , Bogucki J.

Annals of Agricultural and Environmental Medicine

2023

tom 30

nr 4

Apoptosis monitoring in human acute leukaemia cells stimulated by Bcl-2 antisense oligonucleotide and BAY K 8644

100%

Kocki J. , Kocki T. , Lancut M. , Bogucka-Kocka A. , Cioch M. , Dmoszynska A. , Wojcierowski J.

Polish Journal of Environmental Studies

2004

tom 13

nr Suppl.2, Part 1

In this study we investigated effects of bcl-2 antisense oligonucleotides (AS) and BAY K 8644 (B), calcium channel agonist, on human leukaemic cells from non-treatment patients with acute myeloblastic leukaemias. Apoptotic cells were observed in electron and fluorescent microscopes. When we examined the effects of AS + B on cells, level of bcl-2 mRNA decreased more as in cells stimulated by AS only. These observations indicate that AS with B in human leukaemic cells disturb cell viability by inducing apoptosis.

New aspects of retinal degeneration:mechanisms and potential neuroprotective strategies

84%

Rejdak R. , Schuettauf F. , Thaler S. , Kocki T. , Zarnowski T. , Zagorski Z. , Turski W. A. , Junemann A. , Zrenner E. , Grieb P.

Acta Neurobiologiae Experimentalis

2006

tom 66

nr 4