Wyniki wyszukiwania - Biblioteka Nauki

1

XII Małopolska Giełda Agroturystyczna w Krakowie

100%

Liberek A.

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nr 2

2

Plasma protein and enzyme antioxidants in children with chronic hepatitis (CHH)

45%

Popadiuk S. , Liberek A. , Renke J. , Szlagatys A. , Wozniak M.

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nr Supplement 1

3

Serum chemerin level, cytokine profile and nutritional status in children with cystic fibrosis

38%

Sznurkowska K. , Kazmierska K. , Sledzinski T. , Zagierski M. , Liberek A. , Szlagatys-Sidorkiewicz A.

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nr 4

4

Fecal lactoferrin, a marker of intestinal inflammation in children with inflammatory bowel disease

38%

Borkowska A. , Liberek A. , Luczak G. , Jankowska A. , Plata-Nazar K. , Korzon M. , Kaminska B.

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nr 3

5

Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children

32%

Kotlowska-Kmiec A. , Bakowska A. , Szarszewski A. , Kaminska B. , Luczak G. , Radys W. , Landowski P. , Brodzicki J. , Korzon M. , Liberek A.

Acta Biochimica Polonica

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2009

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tom 56

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nr 3

433-438

EN

The pathomechanism of Helicobacter pylori action upon gastric mucosa and its role in the pathogenesis of gastritis have not been fully elucidated. The aim of this study was to evaluate the most prevalent lymphocyte subpopulations of the gastric mucosa in gastritis in children, as well as to evaluate the expression of Fas and Fas ligand receptors (FasL), periapoptotic markers of gastric mucosa lymphocytes before and after H. pylori eradication. Forty nine patients aged 6 to 17 years, investigated due to chronic abdominal pain, were studied. The obtained tissue samples were analysed by immunohistochemistry. Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNγ) and Fas and FasL proteins in the gastric mucosa. B and T helper lymphocytes were found to play a major role in the inflammatory infiltration in the gastric mucosa in children during H. pylori infection. Their expression was found to decrease after eradication. The enhanced expression of Fas receptor on lymphocytes before treatment and a decrease of this expression after eradication of H. pylori were shown. It was demonstrated that there is a correlation between CD4 and Fas receptor expression that may induce apoptosis of the helper lymphocytes in infected children.

6

Graves' disease, celiac disease and liver function abnormalities in a patient - clinical manifestation and diagnostic difficulties

32%

Gora-Gebka M. , Wozniak M. , Cielecka-Kuszyk J. , Korpal-Szczyrska M. , Sznurkowska K. , Zagierski M. , Jankowska I. , Plata-Nazar K. , Kaminska B. , Liberek A.

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tom 61

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nr 2

EN

Autoimmune diseases due to probable common pathogenesis tend to coexist in some patients. Complex clinical presentation with diverse timing of particular symptoms and sophisticated treatment with numerous side effects, may cause diagnostic difficulties, especially in children. The paper presents diagnostic difficulties and pitfalls in a child with Graves' disease, celiac disease and liver function abnormalities.

7

Transforming growth factor beta1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts

26%

Liberek A. , Kmiec Z. , Wierzbicki P. M. , Jakobkiewicz-Banecka J. , Liberek T. , Luczak G. , Plata-Nazar K. , Slominska-Fraczek M. , Kaszubowska L. , Gabik-Ciminska M. , Wegrzyn A.

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2013

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tom 60

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nr 4

EN

Previously published studies on levels of the transforming growth factor-β1 (TGF-β1) protein and mRNA of the corresponding gene in patients suffering from inflammatory bowel diseases (IBD) gave varying results, leading to contradictory conclusions. To solve the contradictions, we aimed to assess longitudinally TGF-β1 protein and mRNA levels at different stages of the disease in children suffering from IBD. The study group consisted of 19 pediatric patients with IBD at the age between 3.5 and 18.4 years. The control group consisted of 42 children aged between 2.0 and 18.0 years. The plasma TGF-β1 concentration was measured with ELISA. mRNA levels of the TGF-β1 gene isolated from samples of the intestinal tissue were assessed by reverse transcription and real-time PCR. Levels of TGF-β1 protein in plasma and corresponding mRNA in intestinal tissue were significantly higher in IBD patients than in controls. TGF-β1 and corresponding transcripts were also more abundant in plasma and intestinal tissue, respectively, in patients at the active stage of the disease than during remission. In every single IBD patient, plasma TGF-β1 level and mRNA level in intestinal tissue was higher at the active stage of the disease than during remission. Levels of TGF-β1 and corresponding mRNA are elevated during the active stage of IBD but not during the remission. Longitudinal assessment of this cytokine in a single patient may help to monitor the clinical course of IBD.