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1 Polish Journal of Microbiology

1 2016

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Serotype-specific pneumococcal status prior to PCV 13 administration in children and adolescents with inflammatory bowel disease

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Banaszkiewicz A. , Targonska B. , Kowalska-Duplaga K. , Karolewska-Bochenek K. , Sieczkowska A. , Gawronska A. , Grzybowska-Chlebowczyk U. , Krzesiek E. , Lazowska-Przeorek I. , Kotowska M. , Sienkiewicz E. , Walkowiak J. , Gregorek H. , Radzikowski A. , Albrecht P.

tom 65

nr 1

The aim of this study was to evaluate the serotype-specific pneumococcal status of children and adolescents with inflammatory bowel disease (IBD) who were naïve to pneumococcal vaccination before administering the 13-valent pneumococcal conjugate vaccine (PCV 13). This was an open, prospective study on children and adolescents aged 5–18 years who had IBD and were naïve to pneumococcal vaccination. A single dose of PCV 13 was administered to each patient. The geometric mean concentrations (GMCs) were measured for all 13 serotypes. A total of 122 subjects completed the study. Prevaccination GMCs ranged from 0.55 μg/ml (serotype 4) to 4.26 μg/ml (serotype 19A). Prior to the administration of PCV 13, high GMCs were detected in older children and adolescents who had IBD and were naïve to pneumococcal vaccination.