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Central beta-adrenergic receptors are involved in the mechanism of porphyrin-induced convulsive effect in mice

100%

Maksym B. , Habdas J. , Plech A.

2005

nr 4

55-63

Study on convulsive effect of meso-tetra-4N-methylpirydyl-porphyrin [P] in rats

100%

Plech A. , Maksym B. , Habdas J.

Pestycydy

2004

nr 3-4

Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma

63%

Drzewiecka A. , Urbanska K. , Matuszak Z. , Pineiro M. , Arnaut L. G. , Habdas J. , Ratuszna A. , Stochel G.

nr 1

We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off < 630 nm). The surviving fraction of the cells decreased about 3-fold (us. non-irradiated cells) for an 81 J/cm dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.