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Vybrané rysy spirituality české katolické církve (1948-1989)

100%

Hanus J.

nr 2-3

341-353

In this article the author seeks to explain some fundamental features of Roman Catholic spirituality in the Bohemian Lands after the Second World War. He demonstrates that this phenomenon was in essence both determined by the 'Roman Catholic Renaissance' of the 1930s and by new tendencies, particularly after the Communist takeover of February 1948. Among these tendencies was its enforced closed nature, fear of persecution, traditionalism, and conservatism, which were mainly the result of the limitations on being in touch with people abroad. On the whole, however, the author believes that Czech Roman Catholicism from the Communist takeover to the collapse of the regime in late 1989, despite all its problems, contributed to Czech culture, and he demonstrates this also in the reception of the Second Vatican Council in Bohemia and Moravia. The spirituality of women, both of nuns and of secular intellectuals, receives special praise in the article.

Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours

32%

Piccinni E. , Chelstowska A. , Hanus J. , Widlak P. , Loreti S. , Tata A. M. , Augusti-Tocco G. , Bianchi M. M. , Negri R.

nr 4

In order to understand better the role of the human Tip60 complex component Gas41, we analysed its expression levels in brain tumours and searched for possible interactors. Two-hybrid screening of a human foetal brain library allowed identification of some molecular interactors of Gas41. Among them we found n-Myc transcription factor. The interaction between Gas41 and n-Myc was validated by pull-down experiments. We showed that Gas41 is able to bind both n-Myc and c-Myc proteins, and that the levels of expression of Gas41 and Myc proteins were similar to each other in such brain tumors as neuroblastomas and glioblastomas. Finally, in order to identify which region of Gas41 is involved in the interaction with Myc proteins, we analysed the ability of Gas41 to substitute for its orthologue Yaf9 in yeast; we showed that the N-terminal portions of the two proteins, containing the YEATS domains, are interchangeable, while the C-terminal portions are species-specific. In fact we found that Gas41 C-terminal portion is required for Myc protein interaction in human.