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1

Immunocytochemical analysis of calretinin in the frontal cortex of chinchilla

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Krawczyk A. , Szalak R. , Jaworska-Adamu J.

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nr 1

EN

The aim of the study was to define morphology and distribution of calretinin (CR) positive neurons in the frontal cortex of adult chinchilla males and intracellular localisation of the protein in this area. The brains of 5 adult chinchilla males were used in the study. CR immunoreactive neurons were shown with peroxidase-antiperoxidase immunohistochemical reaction using a specific monoclonal antibody. Intensive CR immunoreactivity was demonstrated mainly in few polymorphic neurons of II, III, and V layers. Cy toplasmic and nuclear reaction product in most CR positive neurons was diffuse and in some neurons of layer V in the form of granules localised peripherally. In a few cells more intensive staining was observed in the nuclei than in the cytoplasm. The results indicate the presence of heteromorphic CR positive neurons in specific lay ers of the frontal cortex. Nuclear localisation of CR in neurons suggests passive transport of this protein, which may affect the nuclear genes. This protein is a neuroprotector maintaining appropriate level of calcium, modulating neuronal activity, and synaptic conduction in the frontal cortex of chinchilla.

2

Insulin receptors in the CA1 field of hippocampus and selected blood parameters in diabetic rats fed with bilberry fruit

88%

Matysek M. , Borowiec K. , Szwajgier D. , Szalak R. , Arciszewski M. B.

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nr 3

3

Distribution and immunohistochemical characteristics of cocaine- and amphetamineregulated transcript-positive nerve elements in the pelvic ganglia of the female pig

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Arciszewski M. B. , Zacharko-Siembida A. , Matysek M. , Szalak R. , Radlińska A. , Obszańska K.

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nr 1

4

Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats

75%

Matysek M. , Arciszewski M. B. , Mozel S. , Szalak R. , Zacharko-Siembida A. , Obszańska K.

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nr 2

5

Influence of oral administration of HMB to pregnant dams on calbindin expression in the dentate gyrus of the hippocampus during postnatal development in spiny mice offspring

75%

Rycerz K. , Krawczyk A. , Jaworska-Adamu J. , Szalak R. , Tomaszewska E. , Dobrowolski P.

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nr 06

EN

The aim of the study was to investigate the morphology, density and immunostaining intensity of calbindin (CB)-positive neurons of dentate gyrus (DG) in new-born (P0) and 21-day-old (P21) male Acomys cahirinus mice from dams receiving β-hydroxy-β-methylbutyrate (HMB) during pregnancy. Different substances administrated to pregnant dams may affect the calcium ion homeostasis which is crucial for the proper brain development of their offspring. DG with hilus (H) plays an important role in memory and learning processes. Calcium levels in DG are regulated by buffering proteins like calbindin D28k (CB). Experimental dams were orally treated with HMB at a dose of 0.2 g/kg b.w. Half of new-born animals were euthanised after birth and the rest after the 21st day of life. The brains were dissected and embedded in paraffin blocks using a routine histological technique. In order to demonstrate CB protein expression an immunohistochemical peroxidase-antiperoxidase reaction was conducted. The results of the study did not reveal important morphological alterations. There were no statistically significant changes in the density of the studied cells either in P0 and P21 animals. However, the authors have demonstrated a statistically significant increase of the average CB-immunostaining intensity in nuclei and cytoplasm in both age groups. It may be a result of a compensation effect to alterations that occurred under the influence of HMB. On the basis of the conducted research, it may be assumed that HMB activity in DG may provide long-term consequences.

6

Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla

75%

Arciszewski M. B. , Szalak R. , Matysek M. , Mozel S.

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7

Colocalization pattern of cocaine- and amphetamine-regulated transcript peptide and parvalbumin immunoreactivity in the hippocampus proper of the chinchilla

71%

Szalak R. , Matysek M. , Kukula-Koch W. , Rycerz K. , Zacharko-Siembida A. , Arciszewski M. B. , Szalak R. , Matysek M. , Kukula-Koch W. , Rycerz K. , Zacharko-Siembida A. , Arciszewski M. B.

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nr 1

8

The influence of bilberry fruit on memory and the expression of parvalbumin in the rat hippocampus

63%

Borowiec K. , Matysek M. , Szwajgier D. , Biała G. , Kruk-Słomka M. , Szalak R. , Ziętek J. , Arciszewski M. B. , Targoński Z. , Borowiec K. , Matysek M. , Szwajgier D. , Biała G. , Kruk-Słomka M. , Szalak R. , Ziętek J. , Arciszewski M. B. , Targoński Z.

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nr 3