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Bone marrow stromal cells in traumatic brain injury (TBI) therapy: True perspective or false hope?

100%

Opydo-Chanek M.

nr 2

Recent studies regard bone marrow stromal cells as a potential candidate for cellular therapy of traumatic brain injury and thus as an attractive alternative for embryonic and fetal stem cells. Numerous experiments indicate that bone marrow stromal cells play an important role in the repair of injured brain tissue and also support healing processes. Findings of in vitro and in vivo studies show that these cells have an ability to differentiate into cells of multiple tissues, including neurons and glial cells and to secrete an array of growth factors and cytokines, which have an influence on repair of damaged tissue. In addition, treatment of traumatic brain injury with bone marrow stromal cells promotes functional recovery of injured animals. Taking this into consideration, there is hope for using bone marrow stromal cells in brain injury therapy, which is very difficult because of specific events that occur in the pathological conditions. However, mechanisms responsible for the observed therapeutic potential of bone marrow stromal cells still remain unclear. The review presents achievements in studies on bone marrow stromal cells as a source of therapeutic benefits in treatment of traumatic brain injury and addresses the question of their possible future use in clinical trials.

Mitotic catastrophe induction in U937 cells by oxazaphosphorines

51%

Mazur L. , Stojak M. , Opydo-Chanek M. , Niemeyer U.

2009

tom 51

17-22

In vitro response of human pathological hematopoietic cellsto fludarabine phosphate

51%

Opydo-Chanek M. , Stojak M. , Mazur L.

tom 54

The present study was undertaken to determine a possible influence of fludarabine (fludarabine phosphate, F-ara-AMP) on the cell viability and count. The experiments were performed in vitro on human acute lymphoblastic MOLT-4 cells, human acute myeloblasts ML-1 cells, and human histiocytic lymphoma U-937 cells. The research was conducted using the spectrophotometric and Beckman Coulter methods. The cell viability was analyzed using MTT assay. The cell count was detected using an electronic Z2 Coulter counter. Temporary changes in the cell viability and count were assessed at 24h and 48h after F-ara-AMP application. The in vitro activity of fludarabine phosphate against MOLT-4, ML-1, and U-937 cells was compared. F-ara-AMP applied at the four concentrations - 250 nM, 500 nM, 750 nM, and 1 цМ - distinctly decreased the viability and count of the pathological hematopoietic cells. The effects of F-ara-AMP on MOLT-4, ML-1, and U-937 cells were dependent on the tested agent and its dose, the time intervals after the agent application, and the cell line used. ML-1 and U-937 cells appeared to be more resistant than MOLT-4 cells to the action of fludarabine phosphate. The in vitro response of the three human pathological hematopoietic cell lines to the F-ara-AMP action, was shown.

(-)-Epigallocatechin-3-gallate enhances cytotoxic effects of epirubicin on U937 cells

45%

Mazur L. , Borowicz P. , Klaput U. , Blicharski K. , Opydo-Chanek M.

Acta Biologica Cracoviensia. Series Zoologia

2015

tom 57