Wyniki wyszukiwania - Biblioteka Nauki

1

Histamine secretion from human mesenteric and adenoidal mast cells

100%

Brzezinska-Blaszczyk E.

Archivum Immunologiae et Therapiae Experimentalis

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1992

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tom 40

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nr 2

2

Aktywacja mastocytów łożyska ludzkiego pod wpływem bakterii beztlenowych izolowanych z dróg rodnych kobiet ciężarnych

63%

Wasiela M. , Brzezinska-Blaszczyk E.

Medycyna Doświadczalna i Mikrobiologia

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2001

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tom 53

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nr 4

3

Cytokiny moduluja biologie mastocytow tkankowych

63%

Brzezinska-Blaszczyk E. , Olejnik A. K.

Postępy Higieny i Medycyny Doświadczalnej

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2002

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tom 56

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nr 6

803-819

4

Wplyw bakterii beztlenowych i mykoplazm izolowanych z drog rodnych kobiet na aktywacje mastocytow szczura

63%

Wasiela M. , Brzezinska-Blaszczyk E.

Medycyna Doświadczalna i Mikrobiologia

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2000

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tom 52

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nr 4

389-396

PL

Nowadays, it is known that mast cells, numerously appearing in all organs and being a source of a wide range of mediators and cytokines, are involved both in physiological and pathological processes. The aim of our study was to examine whether vaginal bacteria, especially those participating in Bacterial vaginosis, are able to activate mast cells to mediators secretion. The study was done on rat peritoneal mast cells. The mast cells were incubated in vitro with suspensions ot Bacteroides capillosus, Actinomyces naeslundii (2 strains), Peptostreptococcus spp., Lactobacillus fermentum (2 strains), Mycoplasma hominis or Ureaplasma urealyticum killed by temperature. Activation of mast cells was estimated on the basis of histamine release. It was established that M. hominis, U. urealyticum and B. capillosus strongly stimulated rat mast cells to histamine secretion (histamine release 53,0%, 17.4% and 10.0%, respectively). Histamine release induced by Peptostreptacoccus spp., A. naeslundii und L. fermentum was lower (at a range of 2.4%-8.2%). The obtained results can suggest that presumably interactions between vaginal bacteria and placental mast cells could influence the course of pregnancy.

5

Mastocyty i fibroblasty - obojetni sasiedzi czy przyjazni partnerzy?

63%

Brzezinska-Blaszczyk E. , Zalewska A.

Postępy Biologii Komórki

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1997

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tom 24

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nr 2

127-143

6

Lipopolisacharydy i kwasy lipotejchojowe stymuluja komorki tuczne szczura do syntezy leukotrienow cysteinowych

63%

Brzezinska-Blaszczyk E. , Rdzany R. S.

Medycyna Doświadczalna i Mikrobiologia

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2006

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tom 58

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nr 3

223-229

PL

W pracy badano odpowiedź komórek tucznych szczura na aktywację pod wpływem LPS S. Entcritidis, E. coli O111:B4 і E. coli O55:В5 oraz kwasów lipotcjchojowych (LTA) S. aureus i B. subtilis. Stwierdzono, że LPS wszystkich bakterii nie aktywuje komórek tucznych do uwalniania histaminy, natomiast znacznie indukuje syntezę i wydzielanie leukotrienów cysternowych. LTA obu gatunków bakterii stymuluje komórki do wydzielania niewielkich ilości histaminy z równoczesną syntezą i wydzielaniem znaczących ilości leukotrienów.

EN

We have investigated the ability of lipopolysaccharides (LPS) and lipoteiehoic acids (LTA) to induce rat peritoneal mast cells to degranulation and histamine release, and to cysteinyl leukotriene (LT) generation. We have stated that LPS Salmonella Enteritidis, LPS Escherichia coli O111 :B4 and LPS E.coli O55:B5 did not activate rat mast cells to degranulation and histamine release. However, LPSs induced LT synthesis and secretion; the strongest stimulant to generation of LT was LPS E.coli O55:B5 (concentration of LT in supernatant was 830.5 ± 15.2 pg/ml). We have also observed that LTA Staphylococcus aureus and LTA Bacillus subtihs stimulated rat mast cells to degranulation and histamine secretion, even though the percentage of the releases histamine was relatively low (10.0 ± 1.4 and 10.4 ± 5.4 at antigen concentration, respectively). At the same time, LTA of both of the bacterial species strongly activate LT generation by mast cells (concentrations of LT in supernatants were 777.9 ± 11.2 pg/ml and 734.0 ± 38.3 pg/ml, respectively, at the antigen concentration 50 ng/ml). Our results have shown that LPS oraz LTA activate rat mast cells to secretion of proinflammatory mediators.

7

Sensitivity of human cutaneous mast cells to anaphylactic and nonimmunological stimuli

63%

Brzezinska-Blaszczyk E. , Zalewska A.

Archivum Immunologiae et Therapiae Experimentalis

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1997

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tom 45

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nr 1

8

Korelacja stezen wybranych cytokin w wydzielinie pochwowo-szyjkowej u ciezarnych kobiet z roznymi mikroskopowymi obrazami tej wydzieliny

51%

Wasiela M. , Krzeminski Z. , Kalinka J. , Brzezinska-Blaszczyk E.

Medycyna Doświadczalna i Mikrobiologia

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2005

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tom 57

|

nr 3

327-333

PL

Celem pracy było ustalenie, w jakim stopniu u kobiet z bakteryjną waginozą wzrasta w środowisku pochwy stężenie czterech cytokin prozapalnych - IL-1α, IL-1ß, IL-6 oraz IL-8 - oraz czy istnieje jakiś wzajemny związek między wzrostem tych stężeń. Uzyskane wyniki wskazują na to, iż w bakteryjnej waginozie w środowisku pochwy wzrasta stężenie cytokin prozapalnych, najbardziej IL-1ß, IL-1α i IL-8, oraz że wzrost ten jest w pewnych przypadkach ze sobą skorelowany.

EN

The aim of this study was to evaluate the rise of the levels of proinflammatory cytokines -IL-1α, IL-1ß, IL-6 and IL-8 in vagina of women with bacterial vaginosis (BV) and if there is any relationship between this levels. One hundred and twenty females between 22nd and 36th week of pregnancy were enrolled in the study. According to the bacterial flora of cervico-vaginal fluid evaluated by Gram stain, all women were divided into three groups. Group I (53 females; 44.2%) - normal bacterial flora, group II (35 females; 29.2%) - intermediate flora, and group with ВV (32 females; 26.6%). The level of IL-1 b in women withBV was over twelve times higher than in women from I group (131.35 and 10.6 pg/mL respectively). The next was the level of IL-1α - about seven times higher (128.45 vs 19.1 pg/mL) and the levels of IL-6 and IL-8, which were 1.7 times higher (16.2 vs 9.7 pg/mL and 656.7 ví 375.3 pg/mL respectively). Except for IL-6 these differences of levels were statistically significant (p<0.05). The levels of IL-1β in group of women with BV correlated strongly with levels of IL-1α (r=0.72; p<0.0001) and weakly with levels of IL-6 (r=0.31; p=0.017). The correlation coefficient between levels of IL-6 and IL-8 rose gradually in II and BV group and reached levels r=0.575; p=0.0014 and r=0.67; p=0.0009 respectively. Our findings show that in vagina of women with BV the levels of proinflammatory cytokines rise, and that the rise of levels is in certain cases correlated.

9

Histamine-releasing properties of guinea pig cardiac mast cells

51%

Czuwaj M. , Brzezinska-Blaszczyk E. , Wyczolkowska J.

Archivum Immunologiae et Therapiae Experimentalis

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1988

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tom 36

|

nr 5

10

Wplyw Mycoplasma hominis i Ureaplasma urealyticum na stezenie wybranych cytokin prozapalnych w wydzielinie pochwowej

51%

Wasiela M. , Brzezinska-Blaszczyk E. , Krzeminski Z. , Kalinka J.

Medycyna Doświadczalna i Mikrobiologia

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2004

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tom 56

|

nr 4

371-376

11

The effect of isoprinosine treatment on histamine release from murine peritoneal mast cells

51%

Brzezinska-Blaszczyk E. , Karczewska M. , Ubysz-Jerzmanowska K.

Archivum Immunologiae et Therapiae Experimentalis

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1992

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tom 40

|

nr 2