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2 Archivum Immunologiae et Therapiae Experimentalis

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Langerhans cells in vulvar lichen sclerosus and vulvar squamous cell carcinoma

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Rotsztejn H. , Trznadel-Budzko E. , Jesionek-Kupnicka D.

Archivum Immunologiae et Therapiae Experimentalis

2006

tom 54

nr 5

363-366

Introduction: Langerhans cells (LCs), specializing in antigen presentation, are a very important part of the skin immune system (SIS). Materials and Methods: Skin biopsies from 22 women with vulvar lichen sclerosus (LS): 15 patients with early and 7 with the late stage of the disease, were evaluated. Five women with vulvar squamous cell carcinoma (SCC) were also examined. The control group consisted of 9 women who underwent plastic surgery of the vulvar region. Immunohistochemical staining was performed on formalin-fixed paraffin-embedded tissues samples using antihuman CD1a antibody (NCL-CD1a-235, Novocastra). Results: Increased numbers of LC stainings were present in early LS, whereas decreased numbers of these cells were present in late LS and in SCC compared with the control group. Conclusions: This study showed that dysregulation of the SIS may lead to suppression of LCs in the vulvar epithelium and may be one of the reasons for a higher tendency for carcinogenesis in the vulvar region.

Do Langerhans cells play a role in vulvar epithelium resistance to squamous cell carcinoma?

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Rotsztejn H. , Trznadel-Budzko E. , Jesionek-Kupnicka D.

Archivum Immunologiae et Therapiae Experimentalis

2007

tom 55

nr 2

127-130

Introduction: Langerhans cells (LCs) are a very important part of the skin immune system. Materials and Methods: Skin biopsies taken from 13 women after the removal of vulvar squamous cell carcinoma (SCC) who had not been treated earlier for any vulvar diseases were investigated. The control group consisted of 12 women who underwent a plastic surgical operation of the vulva region. Immunohistochemical staining was performed on formalin-fixed, paraffin-embedded tissues samples using antihuman CD1a antibody (NCL-CD1a-235, Novocastra). Results: This study showed a large decrease in LCs in vulvar SCC. Conclusions: It is postulated that the reduction in the number of LCs may be one of the reasons for a higher tendency of carcinogenesis in the vulvar region. Their role as a main element of the skin immune system in the initiation of this process needs further investigation. It is possible that research on LCs in the skin will cast a new light on their role and even contribute to the prophylaxis and treatment of skin and mucosa carcinomas.