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The effect of ghrelin on the ACTH and cortisol responses to mannan oligosaccharide treatment in growing lambs

100%

Pierzchala-Koziec K. , Zubel J.

tom 50

23-27

Rola greliny w modulowaniu proliferacji limfocytow u jagniat

100%

Zubel J. , Pierzchala-Koziec K.

Folia Universitatis Agriculturae Stetinensis. Zootechnica

2006

tom 48

37-43

The effect of ghrelin on the opioid responses to mannan oligosaccharides treatment in growing lambs

80%

Pierzchala-Koziec K. , Zubel J. , Kanitz E.

2006

tom 48

25-29

Dose dependent effect of mannan on the in vitro lymphocyte proliferation in animals

80%

Zubel J. , Pierzchala-Koziec K. , Sendor P.

tom 50

17-21

Fat resistin and adiponectin mRNA expression is modulated by glucocorticoids in mice

80%

Zubel J. , Pierzchala-Koziec K. , Oclon E. , Latacz A.

tom 54

It is known that obesity is associated with a state of chronic low-level inflammation. Some data indicate that obesity- related stress could increase the hypothalamo-pituitary-adrenal axis activity. This leads to a rise in the plasma glucocorticoid level, which induces the development and differentiation of preadipocytes. Thus, the present study was performed to examine the effect of glucocorticoids on the expression of resistin and adiponectin mRNAs in adipose tissue during acute and chronic inflammation in mice. The results of the study showed an increase in the expression of resistin mRNA and a decrease in the expression of adiponectin mRNA during chronic inflammation (obese animals). Synthetic glucocorticoids changed the expression of both adipokines in a different manner according to the state of inflammation. To sum up, the action of glucocorticoids in adipose tissue depends on the immune system activity.

Proinflammatory factors increased ghrelin synthesis and secretion in growing lambs

80%

Zubel J. , Pierzchala-Koziec K. , Oclon E. , Fedorczak J.

2009

tom 51

33-37

Udzial opioidow w modulacji immunosupresyjnego dzialania glikokortykoidow u owiec

80%

Pierzchala-Koziec K. , Zubel J. , Drozdz A.

Roczniki Naukowe Zootechniki. Suplement

2001

nr 12

71-77

Udział opioidów w regulacji cyklu rujowego owiec

71%

Pierzchala-Koziec K. , Zubel J. , Drozdz A. , Kepys B. , Rzasa J.

nr 1

Subdiaphragmatic vagotomy does not protect against the increase of noradrenergic response of the rat

61%

Wieczorek M. , Kobrzycka A. , Hubner M. , Oclon E. , Zubel J. , Swiergiel A.

tom 75

nr Supl.

BACKGROUND AND AIMS: Peripheral administration of gram-negative bacteria endotoxin – lipopolisaccharide (LPS) is known to activate the hypothalamo-pituitary adrenal axis (HPAA) and brain noradrenergic systems. We studied the vagotomized rats responses to peripherally administered LPS using the HPLC-ED to measure the concentration of noradrenaline and their metabolite MHPG in various brain regions. METHODS: Rats were submitted to subdiaphragmatic vagotomy and after 30 days we used them for experiments. They were injected with saline (100 μl ip) and LPS (10 μg/100 μl ip) in random order, and two hours after injection they were euthanized. They brains where removed from the skull and we isolated the hypothalamus, amygdala, prefrontal medial cortex, hippocampus periaqueductal gray matter and the brainstem and submitted for chromatographic analysis. RESULTS: Future chromatographic analysis indicates, that subdiaphragmatic vagotomy did not protect against increase of noradrenaline concentration in analyzed brain regions. In case of LPS injected animals we observed increased noradrenaline concentration versus saline injected ones. These results were comparable with those observed in sham operated rats. CONCLUSIONS: There results suggest that there may be compensatory mechanisms, responsible for transferring of immune signal to the brain, and develop during such a long time of recovery after subdiaphragmatic vagotomy. Supported by NCN, grant no. UMO-2012/07/B/NZ4/00205