Wyniki wyszukiwania - Biblioteka Nauki

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

Znaleziono wyników: 3

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Fat grafts in the reconstruction and treatment of chronic wounds

100%

Noszczyk B. , Krześniak N.

Polish Journal of Surgery

2013

tom 85

nr 12

937-941

Vertical rectus abdominis myocutaneous flap inguinal reconstruction combined with lymphatic venous anastomosis after oncological resection – a case report and literature review

80%

Radziszewska J. , Krześniak N. , Radziszewski M. , Gierej P.

OncoReview

2023

tom 13

nr 4

103-108

Introduction: The vertical rectus abdominis myocutaneous (VRAM) flap is one of the possible solutions to cover large tissue defects after oncological resection in the inguinal region. Its efficacy can be impaired due to recipient site tissue damage following radiotherapy as well as due to lymphadenectomy, often resulting in lymphoedema and persistent lymphatic leakage. Case report: Contralateral VRAM reconstruction was performed in a 50-year-old male patient with a nonhealing inguinal wound following right thigh sarcoma excision and radiotherapy. To improve the flap performance, we combined VRAM surgery with lymphatic venous anastomosis (l VA) to the contralateral inferior epigastric vein. An immediate stoppage of the lymphatic leakage occurred as well as after the surgery a lower extremity edema reduction was observed (varying from 2 to 7 cm of leg circumference, depending on the level of the measurement). Discussion: It is possible that LVA enabled proper flap healing and improved lymphatic drainage; however, it is also probable that a similar effect could have been achieved with the VRAM flap alone. Conclusion: This case report indicates that l VA could improve VRAM flap performance in inguinal reconstruction procedures and reduce lymphedema and lymphorrhea; however, further research is needed.

Gene expression alterations induced by low molecular weight heparin during bowel anastomosis healing in rats

41%

Krześniak N. , Paziewska A. , Rubel T. , Skrzypczak M. , Mikula M. , Dzwonek A. , Goryca K. , Wyrwicz L. S. , Jarosz D. , Laubitz D. , Woszczyński M. , Bielecki K. , Ostrowski J.

Acta Biochimica Polonica

2011

tom 58

nr 1

79-87

Colon anastomosis is therapeutically challenging because multiple, usually undetectable factors influence a spectrum of repair mechanisms. We hypothesized that low molecular weight heparins, routinely administered perioperatively, may differentially affect gene expression related to colon healing. Twenty pairs of untreated and enoxaparin-treated rats underwent left-side hemicolectomy with a primary end-to-end anastomosis. Normal colon and anastomotic bowel segments were resected on day 0 and on days 1, 3, 5, and 7 after surgery, respectively. Serial anastomosis transverse cross-sections were evaluated microscopically and by microarray (Rat Genome 230 2.0, Affymetrix). Differentially expressed probe sets were annotated with Gene Ontology. We also examined the influence of enoxaparin on fibroblast proliferation and viability in vitro. Among the 5476 probe sets, we identified differential expression at each healing time point, yielding 79 subcategories. Most indicated genes were involved in wound healing, including multicellular organismal development, locomotory behavior, immune response, cell adhesion, inflammatory response, cell-cell signaling, blood vessel development, and tissue remodeling. Although we found no intensity differences in histological features of healing between enoxaparin-treated and control rats, treatment did induce significant expression changes during early healing. Of these changes, 83 probe sets exhibited at least twofold changes and represented different functional annotations, including inflammatory response, regulation of transcription, regulation of apoptosis, and angiogenesis. Fibroblast culture confirmed an anti-viability effect of enoxaparin. Enoxaparin affects colon wound-related gene expression profiles, but further studies will resolve whether heparin treatment is a risk factor after intestinal surgery, at least in some patients.