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1 Acta Biochimica Polonica

1 2003

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Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell.

100%

Ochocka A.-M. , Pawelczyk T.

nr 4

1097-1110

Phospholipase C (PLC, EC 3.1.4.11) is an enzyme crucial for the phosphoinositol pathway and whose activity is involved in eukaryotic signal transduction as it generates two second messengers: diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). There are four major types of phospholipase C named: β, γ, δ and the recently discovered ε, but this review will focus only on the recent advances for the γ isozymes of PLC. So far, four d isozymes (named γ1-4) have been discovered and examined. They differ with regard to cellular distribution, activities, biochemical features and involvement in human ailments.