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Sweat secretion from a single sweat gland can be monitored by using microtube or by visual observation of the skin region using a microscope or video recorder. Another method described in the present paper is based on perfusion with ultra-low conductive water of a small region of the skin with only one sweat pore. Sweat secreted from a gland is reach in ions comparing to perfusion fluid and therefore increases conductivity of the perfusion fluid. Conductivity of the perfusion fluid is measured on inlet and outlet of the measurement probe and the difference is amplified and sampled by an analog-to-digital converter controlled by developed software on PC. The goal of the present paper is to present an improved system of single sweat glands monitoring.
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Content available remote Preventive systems for the late complications of diabetes
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Aim of this work is to review and characterize methods and systems that are used to prevent onset and to slow down the progression of the late complications of diabetes. Two groups of methods and systems that might be used to prevent or to slow down the progression of the late complications of diabetes are characterized in this paper. Each of these two groups serves a different purpose. The first group is composed of the systems that facilitate a maintenance of strict metabolic control in diabetic patients, i.e. the systems which are used for monitoring and treatment of diabetes. The second group contains systems that are aimed at screening/monitoring or treatment of the risk factors or the early signs of the late complications. Obesity increases risk of diabetes and its complications. Thus, body mass monitoring and control systems are examples of the tools that belong to this group. Other examples include the diabetic retinopathy telescreening systems and the systems for monitoring of the diabetic foot syndrome.
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Content available remote A system for monitoring of sweat secretion from four sweat glands
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A method providing monitoring of activity of a single sweat gland by measurement of electric conductivity of perfusion solution has been developed recently. The aim of this project was to design and develop a mesurement system employing the electric conductivity method, which could simultaneously monitor the sweat secretion from four sweat glands. The measurement chamber was developed to use in the measurement system. In vivo measurements using developed system were carried out. Detailed measurement procedure has been presented. The results proved proper operation of the designed system.
EN
Insulin sensitivity (IS) is one of the important diagnostic parameters used in treatments of diabetes, hypertension and other diseases as well as during evaluation of new drug therapies. Euglycaemic glucose clamp is the most accurate method of the IS measurement. Effectiveness of this procedure depends on accuracy of the tissue glucose utilization measurements (GU) and proper realization of the insulin infusion. Application of the accurate glucose control algorithm, sampling site, sampling frequency, duration of the procedure are also very important factors. Possible technical realization includes manual, semi-automatic and automatic modes. Recently the computerized semi-automatic system realizing this type of measurement has been designed and developed in the IBBE PAS. A developed system consist of control unit, infusion unit, glycaemia measurement unit and printer. Endogenous glucose secretion is suppressed by insulin infusion, which is determined according to individual patients parameters. The newest version of the measurement procedure allows to realize euglycaemic or normoglycaemic clamp studies. TISS system is inexpensive and easily operated by one person from middle medical staff. Till now GU measurements using TISS system were performed on over 200 patients in 4 Polish clinical centers. Developed and clinically tested TISS system seems to provide satisfying quality of the GU measurement in men.
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Background: Patients with diabetic neuropathy exhibit a higher foot temperature than those without neuropathy and they are at risk for foot ulceration. Ambient temperature and foot ulceration additionally influence foot temperature in such patients. The aim of the study was to assess the influence of ambient temperature on foot temperature in patients with an ulcer on one of the feet. Methods: Miniature temperature data loggers were used for the monitoring of foot skin and ambient temperature. Twenty patients with diabetic neuropathy and ten healthy subjects were monitored for about 24 h each. Results: The temperature of the foot with an ulcer correlates significantly with ambient temperature, with the slope of the regression line of 0.09. The temperature of the non-ulcerated foot also correlates significantly with ambient temperature, with the slope of 0.31, however the correlation coefficient and the slope are significantly higher than in the case of the foot with an ulcer. The difference of temperature of the foot with an ulcer and temperature of the foot without an ulcer correlates well with ambient temperature with the slope of _0.219. The temperatures of left and right feet were studied as a function of ambient temperature in healthy individuals and there were no statistically significant differences between correlation coefficients and slopes. Conclusions: It is apparent that ambient temperature influences foot temperature even during foot ulceration. Thus ambient temperature should be taken into consideration in any application when foot temperatures are important, especially in the prediction of diabetic foot ulceration.
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The aim of the present study was to verify a system for continuous monitoring of feet temperature. The temperature measurement system developed in cooperation of the Center for Biomedical Technology (Krems, Austria) and Digilog Inc. (Perg, Austria) company was used for monitoring of the skin temperature on foot. The temperature monitoring devices are wirelessly controlled and they could be encapsulated in order to achieve waterproofing and facilitate disinfection with liquid disinfectant. The skin temperature measurements were performed every 1 or 5 minutes. Two healthy subjects were monitored for 7-9 days. The preliminary system application showed its usefulness in continuous temperature monitoring of feet.
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B-cell chronic lymphocitic leukemia (B-CLL) is the most common type of leukemia in adults. The aim of the work was to design and implement a computer registration and monitoring system for patients with B-CLL. The developed BIAL system comprises modules allowing for registration of the data related to patient's identification, patient's general state (e.g. objective examination, phenotype, etc.), laboratory examinations (biochemical, immunological and cytogenetical), applied treatment (chemo- and/or immunotherapy) and evaluation of immunotherapy on an animal model. Selected biochemical and immunological parameters can be presented on charts, to facilitate evaluation of patient's state, the course and outcome of the treatment. The BIAL system was preliminary verified basing on the data registration of 8 B-CLL patients treated with chemo- or immunotherapy in the Clinic of Hematooncology and Bone Marrow Transplantation MU in Lublin. It was found to be comprehensive yet easy to learn and use. The system should facilitate the current treatment of the B-CLL patients and should make a foundation for the future multi-patients data analysis leading to elaboration of the criteria for selection of the optimal treatment regimen for patients with B-CLL.
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Content available remote Comparison of the wound area assessment methods in the diabetic foot syndrome
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The paper presents results of comparison of the wound area assessment methods in the diabetic foot syndrome (DFS). Wound size is a basic parameter that is used to evaluate efficacy of the applied treatment. Four measurement methods were used: the rulers, the planimetric Visitrak (Smith & Nephew, England), the Silhouette (Aranz Medical, New Zealand) applying lasers, digital photography and planimetry as well as the patient's module of TeleDiaFoS telecare system with the foot scanning capabilities. Study group consisted of 18 DFS patients. Nineteen wounds were successfully measured with all 4 methods. The results of the Visitrak and the Silhouette can be used interehangeably (r = 0.994, slope = 1.01, intercept = 0.154 cm2). For the other systems strong linear relationships exist that can be used to convert the wound area measured with one method to the corresponding value of another method. The correlation coefficients higher than 0.985 were obtained in ease of 3 systems: Visitrak, Silhouette and TeleDiaFoS. The TeleDiaFoS system can provide a physician with the patient-self-taken wound images that can be used for reliable assessment of the wound healing process during home tele-monitoring of the DFS patients.
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