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Prevalence of Polyoma BK virus ( BKPyV) , Epstein-Barr virus (EBV) and Human Papilloma virus (HPV) in oropharyngeal cancer

100%

Polz-Gruszka D. , Morshed K. , Jarzynski A. , Polz-Dancewicz M.

nr 4

The aim of this study was to analyze the prevalence of BK virus, Human Papillomavirus and Epstein-Barr virus in oropharyngeal cancer, and to test our hypothesis that BKV/HPV/EBV co-infection plays a role in oropharyngeal squamous cell carcinoma. The correlation between viral infection, OSCC, anatomic location, pre-treatment staging, evidence of metastases to lymph nodes, and grading was also investigated. The examination samples were collected from 62 patients from paraffin tissue blocks. Males (90.3%) with, smoking (83.9%) and alcohol abuse (67.7%) problems prevailed in the studied group. G2 histological type was recognized in 80.6% cases. T4 (77.4%) and N2 (56.5%) traits occurred in the majority of patients. No cases of metastasis were observed (M0 100%). HPV – 24.2%, EBV – 27.4% and BKV 17.7% were detected in the studied samples. We observed co-infection EBV/BKV in 8% of cases, HPV/BKV in 4.8%, and HPV/EBV in 9% cases. Only in two cases co-infection of all three viruses was found.

Prevalence of herpesviruses in patients with larynx and hypopharynx squamous cell carcinoma

100%

Polz D. , Polz-Dacewicz M. , Morshed K. , Pedrycz-Wieczorska A.

nr 2

The aim of this study was the analysis of the prevalence of Herpesviridae (EBV, CMV, HSV-1) among patients with head and neck cancers (larynx and hypopharynx squamous cell carcinoma). Correlation between viral infection, HNSCC, alcohol use, tobacco smoking, demographic data (gender, age, place of residence, occupation), anatomic location, pre-treatment staging, evidence of metastases to lymph nodes, and grading was also investigated. The examination samples were collected from paraffin-blocks tissues, from 35 patients. The laboratory part of investigation involved: isolation of DNA from histopathological specimens, qualitative analysis of DNA comprising of amplification of human ß-globin gene (reference gene) fragment, electrophoresis of amplification products of the gene fragment, quantitative DNA analysis (using spectrophotometric method), and viral DNA amplified by the nested-PCR method. There was a statistically significant correlation between T and tobacco smoking, and T and alcohol use. There was no statistically significant correlation between the presence of EBV, CMV, HSV-1 and G and epidemiological features such as place of residence.

Bioimpedance vector pattern in head and neck squamous cell carcinoma

88%

Malecka-Massalska T. , Smolen A. , Zubrzycki J. , Lupa-Zatwarnicka K. , Morshed K.

nr 1

Correlation between epidemiological, clinical and pathological features and HPV 16 infection in patients with laryngeal squamous cell carcinoma

75%

Morshed K. , Polz-Dacewicz M. , Szymanski M. , Polz D. , Trojanowski P. , Abushammalah R. , Smolen A.

nr 1

17-20

HPV DNA was amplified by the nested-PCR method to identify E6/E7 HPV 16 from 72 deep-frozen (-70°C) specimens of LSCC tumours collected after a total laryngectomy. HPV was identified in 38.9% of the specimens. There was no statistically significant correlation between the presence of HPV and epidemiological, clinical, and pathological features, and recurrence. There was no statistically significant correlation between the presence of HPV and survival. HPV infection is not likely to influence survival rates as an independent prognostic factor in patients with laryngeal cancer. The presence of HPV infection in 38.9% of the cases suggest a possible role in the aetiology of laryngeal cancer and support the role of high-risk types of HPV 16 in LSCC.

Immunohistochemical study of retinoblastoma protein expression in laryngeal squamous cell carcinoma according to low and high overexpression

75%

Morshed K. , Korobowicz E. , Skomra D. , Szymanski M. , Polz-Dacewicz M. , Golabek W. , Smolen A.

tom 52

nr 4

The aim of this study was to determine the possible relevance of the retinoblastoma protein (pRb) expression in laryngeal cancer as a prognostic criterion and to analyse the correlation between the expression and clinical and pathological features vs. survival rates. The immunohistochemical staining was used to detect the expression of pRb in 130 samples of laryngeal cancer and in 22 specimens of laryngeal nodules. pRb nuclear expression was detected in 90 (69%) out of 130 patients with laryngeal squamous cell carcinoma (LSCC), and in three (13.6%) samples of laryngeal nodules. pRb expression correlated with high tumour stage. Patients with high expression of pRb (≥ 50%) had worse survival rates than patients with low expression (< 50%) in 3- and 5-year overall survival observation. A multivariate analysis of survival showed that pRb expression was not an independent prognostic factor in laryngeal cancer. The expression of pRb in LSCC is connected with higher tumour stage.