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3 Żołnierek J.

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The first line therapy for intermediate/ high risk patients with advanced renal cell carcinoma according to therapeutic program B.10

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Żołnierek J.

OncoReview

2023

tom 13

nr 2

48-57

The purpose of this article is to discuss the use of therapeutic options for the first-line systemic treatment of patients with advanced renal cell carcinoma under the B.10 drug program effective in Poland as of May 2022 - with a focus on intermediate and high-risk patient populations according to the IMDC. The specific situation created by reimbursement conditions with the exclusion of regimens combined with a tyrosine kinase inhibitor and immune checkpoint inhibitors along with the marginalisation of the use of an mTOr inhibitor necessitates a choice between two-drug immunotherapy or an antian giogenic drug in monotherapy. In this context, choosing the right treatment in the context of specific clinical situations is a challenge.

Abiraterone acetate – 10 clinically relevant facts

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Żołnierek J.

OncoReview

2021

tom 11

nr 3

80-84

Prostate cancer is one of the most frequently diagnosed cancers in men. Number of newly diagnosed cases is increasing due to several factors and the most important ones seem to be: population ageing and more sensitive diagnostic procedures. Secondary – the higher efficacy of treatment with its influence on improving patients’ overall survival and the specific mechanism of action of drugs used in systemic therapy lead to growing population of men suffering from prostate cancer in general and, specifically – patients with castration resistance. It is hormone therapy to play the key role in systemic treatment of prostate cancer with increasing significance of novel drugs focused on inhibition of molecular signal transduction mediated by androgen receptor. Abiraterone acetate is the representative of this therapeutic class. The paper describes the most clinically relevant data regarding the drug.

Wobec ideologii postideologii

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Żołnierek J.

Sensus Historiae. Studia interdyscyplinarne

2013

nr 1(10)

115-130

Some authors think we live in post-ideological times. It’s possible, however, in legacy of Lenin and Marks, to lose this certainty. In preface and afterword of „Revolution at the Gates” Slavoj Žižek argues that Lenin is the most important thinker for the contemporaneity. The most crucial period of his life was between two revolutions, in February and October of 1917. Today — Slovenian intellectual believes — we also live in crucial period. For us, our February was the decline of the Soviet Union. Our October is, however, placed somewhere in the future, and — as such — unknown. In such situation we should be like Lenin between the revolutions. We should follow his pattern and act like he did, fight. The only weapon we have is our pencil. The ammunition we should use in fight for the future are Marx writings. In this paper I try to show the importance of Žižek for our thinking about present times in capitalistic world. Maybe indeed we should change it, or — at least — try to undermine, in our thinking, the present “natural” state of things?