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Multiplexed Immunobead-Based Cytokine Profiling in patients with ovarian cancer

100%

Wyciszkiewicz A. , Lach M. , Kalinowska A. , Michalak S. , Nowakowski B.

European Journal of Translational and Clinical Medicine

2021

tom 4

nr 2

31-43

Due to late diagnosis, ovarian cancer is the most deadly gynecologic malignancy. Inflammation is one of the risk factors of ovarian cancer and the inflammatory response implicates all stages of tumorigenesis. The purpose of this study was to analyze the concentration of molecules, which can take part in malignant processes. We analyzed patients with ovarian cancer, with endometriosis and healthy controls. Thirty-seven analytes were measured in serum using BioPlex Pro Human Inflammation Panel. We were able to detect 28 of the proteins among the studied groups. We found a significant increase in 22 of the tested molecules (BAFF, Chitinase3-like 1, IFN-alpha2, IFN-beta, IFN-gamma, IFN-lambda2, IFN-lambda1, gp130, IL-2, IL-12 (p40), IL-11, IL-32, IL-35, MMP3, Osteocalcin, Pantraxin-3, sCD163, TNFRSF8, sIL-6Ralpha, STNF-R1, STNF-R2, and TSLP) in the ovarian cancer group in comparison to the healthy controls. Two of them (IL-20, MMP1) did not show significant differences between groups. Moreover, we identified decreased concentrations of APRIL and osteopontin in ovarian cancer vs. healthy controls. While this study is a preliminary report, we hope this will encourage a further use of multiplex analysis in ovarian cancer biomarker research.

Encouraging Pro-environmental Behaviour Through an Educational Mobile Application: Preliminary Insights from Early Adopters

72%

Duda E. , Anacka H. , Kowal J. , Nowakowska I. , Obracht-Prondzyńska H. , Geirbo H. C. , Radziszewski K. , Romanowska M. , Wyciszkiewicz A. , Zawieska J.

International Journal of Pedagogy, Innovation and New Technologies

2023

tom 10(1)

64-78

This article aims to explore the extent to which the educational mobile application PULA supports and promotes pro-environmental behaviours, identify the most utilised functionalities by early adopters, and explore the least engaged functionalities. The study employs a quantitative approach based on data collected from the application. The analysis provides a comprehensive understanding of users' experiences and behaviours within the application, contributing valuable insights into its potential to foster pro-environmental attitudes and behaviours. The results suggested that the users, especially women, were generally interested in the learning activities. Pro-environmental transport-related activities were also frequently undertaken by the users. While women tended to split their time into various functionalities of the application, men focused mainly on the transport-related ones. This research contributes to the emerging field of using educational mobile applications for promoting pro-environmental behaviour. The study's focus on early adopters provides unique perspectives on the mechanisms behind behaviour change and offers implications for future interventions. The findings of this study can impact environmental conservation efforts. By encouraging pro-environmental behaviour through an accessible mobile application, a broader audience can be reached and motivated to adopt greener habits. The insights gained from this research can inform the design and development of future applications to foster sustainable practices, benefiting society and contributing to building a more sustainable future.