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1 Acta Neurobiologiae Experimentalis

1 2013

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Acetylcholine receptors underlying the cholinergic modulation of corticothalamic transmission from layer 6 input to posteromedial thalamic nucleus

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Nersisyan S. , Bekisz M. , Kublik E. , Granseth B. , Wrobel A.

nr Suppl.1

We have previously shown that cholinergic agonist carbachol modulates synaptic transmission of layer 6 corticothalamic input to posteromedial nucleus of the thalamus. In rat brain slices application of carbachol depresses synaptic responses to stimulation of corticothalamic fibers but enhances their frequency facilitation. Here we show that carbachol acts via activation of muscarinic receptors, because application of muscarinic antagonist (scopolamine or atropine) abolished both: depression of corticothalamic EPSPs and increase of frequency facilitation. In contrary, high concentration (100 µM) of specific nicotinic agonist DMPP (dimethylphenylpiperazinium) neither depressed corticothalamic responses nor enhanced the frequency facilitation. Surprisingly, low concentration of DMPP (10 µM) increased corticothalamic EPSPs, but did not change the frequency facilitation of corticothalamic transmission. This research and SN were supported by the European Union Regional Development Fund through the Foundation for Polish Science within the frames of International PhD Program in Neurobiology