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1

Leu-enkephalin immunoreactivity in the pig pineal gland

100%

Przybylska-Gornowicz B. , Lewczuk B.

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nr 2

2

Opioid involment in the control of the pineal gland activity - a preliminary study

80%

Lewczuk B. , Przybylska-Gornowicz B. , Wyrzykowski Z. , Kostyra E.

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nr 3

3

Neuropeptide Y as a presynaptic modulator of norepinephrine release from the sympathetic nerve fibers in the pig pineal gland

80%

Ziolkowska N. , Lewczuk B. , Przybylska-Gornowicz B.

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nr 1

EN

Norepinephrine (NE) released from the sympathetic nerve endings is the main neurotransmitter controlling melatonin synthesis in the mammalian pineal gland. Although neuropeptide Y (NPY) co-exists with NE in the pineal sympathetic nerve fibers it also occurs in a population of non-adrenergic nerve fibers located in this gland. The role of NPY in pineal physiology is still enigmatic. The present study characterizes the effect of NPY on the depolarization-evoked 3H-NE release from the pig pineal explants. The explants of the pig pineal gland were loaded with 3H-NE in the presence of pargyline and superfused with Tyrode medium. They were exposed twice to the modified Tyrode medium containing 60 mM of K+ to evoke the 3H-NE release via depolarization. NPY, specific agonists of Y1- and Y2-receptors and pharmacologically active ligands of a2-adrenoceptors were added to the medium before and during the second depolarization. The radioactivity was measured in medium fractions collected every 2 minutes during the superfusion. NPY (0.1 - 10 μM) significantly decreased the depolarization-induced 3H-NE release. Similar effect was observed after the treatment with Y2-agonist: NPY13-36, but not with Y1-agonist: [Leu31,Pro34]-NPY. The tritium overflow was lower in the explants exposed to the 5 μM NPY and 1 μM rauwolscine than to rauwolscine only. The effects of 5 μM NPY and 0.05 μM UK 14,304 on the depolarization-evoked 3H-NE release were additive. The results show that NPY is involved in the regulation of NE release from the sympathetic terminals in the pig pineal gland, inhibiting this process via Y2-receptors.

4

The study of melatonin release from pineal gland of the domestic pig using a perfusion culture technique

80%

Lewczuk B. , Przybylska-Gornowicz B. , Wyrzykowski Z.

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1997

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tom 57

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nr 5

5

Postnatal changes in adrenergic and neuropeptide Y - containing nerve fibres in pineal gland of the pig. An immunohistochemical study

80%

Przybylska-Gornowicz B. , Kaleczyc J. , Majewski M. , Lewczuk B.

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nr 4

6

Demonstration of nerve fibers immunoreactive to peptide N-terminal histidine C-terminal isoleucine [PHI] and vasoactive intestinal peptide [VIP] in the pig pineal gland

80%

Nowicki M. , Lewczuk B. , Papiewska M. , Przybylska-Gornowicz B.

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nr 3

7

Localization of NADPH-diaphorase activity in the pineal gland of the domestic pig

80%

Lewczuk B. , Wojtkiewicz J. , Majewski M. , Przybylska-Gornowicz B.

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2001

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tom 39

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nr 2

8

Immunohistochemical localization of substance P in the pineal gland of the domestic pig

80%

Przybylska-Gornowicz B. , Lewczuk B. , Moller M.

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nr 2

9

Diurnal rhythms of pinealocyte ultrastructure, pineal serotonin content and plasma melatonin level in the domestic pig

80%

Lewczuk B. , Nowicki M. , Prusik M. , Przybylska-Gornowicz B.

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nr 3

10

The ultrastructure of the pineal gland in the goat

80%

Lewczuk B. , Przybylska-Gornowicz B. , Kujawska M. , Nowakowska I.

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nr 2

11

Influence of 4-day long treatment with vasoactive intestinal peptide on ultrastructure and function of the rat pinealocytes in organic culture

80%

Nowicki M. , Lewczuk B. , Przybylska-Gornowicz B.

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2002

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tom 40

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nr 1

12

Calcium concrements in the pineal gland of the Arctic fox (Vulpes lagopus) and their relationship to pinealocytes, glial cells and type I and III collagen fibers

71%

Bulc M. , Lewczuk B. , Prusik M. , Gugolek A. , Przybylska-Gornowicz B.

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tom 13

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nr 2

13

The influence of methisoprinol administered in ovo on the morphological structure of the spleen in turkeys

61%

Stenzel T. , Tykalowski B. , Lewczuk B. , Przybylska-Gornowicz B. , Andrzejewski M. , Koncicki A.

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tom 13

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nr 2

14

Badania nad wplywem preparatu ziolowego podawanego maciorom na ultrastrukture komorek trzustki zewnatrzwydzielniczej u prosiat

61%

Gajecki M. , Przybylska-Gornowicz B. , Guz M. , Pirus K. , Przewoski W. , Przala F.

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tom 52

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nr 09

593-595

EN

The aim of the studies was to establish on the basis of ultrastructural examinations whether the tested herbaceous preparation added to the feed of sows may influence pancreas activity (pars vesicularis) of suckling piglets. The tested preparation contained: Folium urtice, Fructus Silybi mariani and Exocarpium fagopyri. The preparation was added to feed once daily at a dose of 20 g/animal from the 90th day of pregnancy to the 28th day of lactation. Pancreas for ultrastructural examinations were collected immediately after slaughter from randomly selected 1 and 21 day-old-piglets. It was found that the examined preparation had a positive effect on sows and also on the pancreas ultrastructure of piglets. Active substances of the examined preparation acting both directly and in interaction with endogenous factors stimulated pancreatic secretion. In older piglets the preparation also intensified exocythose.

15

Effects of diets with different contents of soybean alpha-galactosides and crude fibre on modification of duodenal microstructure and selected parameters of nutrient utilization in young turkeys

61%

Juskiewicz J. , Jankowski J. , Zdunczyk Z. , Lecewicz A. , Przybylska-Gornowicz B. , Zieba M.

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nr 4

EN

The aim of the present study was to assess the physiological response of growing turkeys’ duodenal surface to dietary replacement of a common dietary component – soybean meal (SBM) with a soy protein isolate (SPI), as this treatment was associated with almost complete removal of α-galactosides from the diet (from 2.44 to 0.15%). Additionally, the utilization of selected dietary ingredients upon dietary treatments was recorded. Effects of raffinose-family oligosaccharides were assessed as well in low- and high-fibre dietary environment (3.5 and 5.3% of crude fibre, respectively). This study revealed that the duodenal morphological parameters were differently affected by dietary treatments at different production stages, i.e. at 4 and 8 weeks of life. Although villus height/crypt depth ratio (VCR) was insignificantly decreased by high-α-galactoside treatment in younger 4-week birds, the presence of these oligosaccharides in the diet positively influenced the VCR index in 8-week turkeys. A similar tendency was observed when calcium retention was considered. Different contents of dietary crude fibre affected the physiological action of α-galactosides, including duodenal crypts depth and phosphorus retention in the 4-week birds, as well as duodenal goblet cells number and nitrogen utilization in the older turkeys. A high content of α-galactosides in the diet resulted in increased hydration of intestinal contents, but without a significant decline in the dry matter digestibility and utilization of nitrogen, calcium and phosphorus. Having in mind the development and physiology of the GIT, it may preliminary be concluded that in later production stages, total withdrawal of soybean α-galactosides from turkeys’ diets does not seem to be nutritionally advisable.

16

Ultrastructural changes of ovarian follicle and corpus luteum after experimental zearalenone mycotoxicosis in bitch

51%

Gajecka M. , Przybylska-Gornowicz B. , Obremski K. , Polak M. , Jakimiuk E. , Skorska-Wyszynska E. , Zielonka L. , Gajecki M.

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tom 11

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nr 4

327-337

EN

The aim of the study was to determine the influence of experimental zearalenone (ZEA) my- cotoxicosis on the ultrastructure of ovaries in bitches receving zearalenone for 100 days per os in the anestrus phase. Experiment has been conducted on 9 sexually mature clinically healthy bitches. The sexually mature animals aged 1-3 years were in anestrus. The dogs have been divided into three groups: EI and Ell, receiving ZEA per os in two dosages (25 μg/kg and 50 μg/kg b.w.) and control animals which received placebo per os. On the last day of experiment, ovariohysterectomy was performed in all the bitches and the uterine samples were submitted to ultrastructural analyses. The study has revealed that long lasting administration of higher dose of zearalenone causes ultrastructural changes in the granular layer of ovarian follicles, which showed due to their biological activity decrease. The changes in the granular layer, atrophy of intercellular connections and the appearance of intercellular spaces can stand for reduced activity of this layer. Changes in morphology of mitochondria, rough endoplasmic reticulum and Golgi apparatus sugest ZEA influence on cell metabolism and secretory processes. It seems therefore that in bitches and other monogastric animals, intoxications induced by this mycotoxin causes ultrastructural changes in granular cells of ovarian follicles.