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1 Acta Biochimica Polonica

1 2012

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Effect of substrate stiffness on differentiation of umbilical cord stem cells

100%

Witkowska-Zimny M. , Walenko K. , Wałkiewicz A. E. , Pojda Z. , Przybylski J. , Lewandowska-Szumieł M.

nr 2

261-264

Tissue formation and maintenance is regulated by various factors, including biological, physiological and physical signals transmitted between cells as well as originating from cell-substrate interactions. In our study, the osteogenic potential of mesenchymal stromal/stem cells isolated from umbilical cord Wharton's jelly (UC-MSCs) was investigated in relation to the substrate rigidity on polyacrylamide hydrogel (PAAM). Osteogenic differentiation of UC-MSCs was enhanced on stiff substrate compared to soft substrates, illustrating that the mechanical environment can play a role in differentiation of this type of cells. These results show that substrate stiffness can regulate UC-MSCs differentiation, and hence may have significant implications for design of biomaterials with appropriate mechanical properties for regenerative medicine.