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1
Content available Fibroblast biological activity on poly(l-lactide) and poly(l-lactide-co-trimethylene carbonate)
100%
Ścisłowska-Czarnecka A. , Pamuła E. , Kołaczkowska E.
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tom Vol. 14, no. 102
7--10
EN
Poly-L-lactide (PLLA) is acknowledged biocompatible polyester. However, it possesses high crystallinity/brittleness/stiffness and requires long time for complete degradation. In the current study we present data on PLTMC, a copolymer of L-lactide and trimethylene carbonate (TMC). Poly(trimethylene carbonate) (PTMC) is characterised by good mechanical properties and rapid degradation rate and for this it might possess new desired features for medical applications. During the experiments, adhesion and activity of fibroblasts cultured on PLLA and PLTMC were studied and compared during two time points of 3 and 5 days. On day 3, the number of adherent fibroblasts was compromised when fibroblasts were cultured in the presence of PLTMC but the proper adherence was recovered by day 5. The same pat-tern was observed when we evaluated some activity parameters of fibroblasts. In particular, the release of proteins and nitric oxide was studied as the increased levels of the mediators might indicate unwanted inflammatory-like condition. Overall, the results suggest that the synthesized PLTMC initially shows unwanted effects on fibroblasts but with the time these effects are abolished. Therefore PLTMC seems to represent a new material that is non-cytotoxic and compatible with the living cells.
2
Content available remote Composites Based on Poly-e-Caprolactone and Calcium Alginate Fibres Containing Ceramic Nanoadditives for Use in Regenerative Medicine
100%
Boguń M. , Stodolak E. , Menaszek E. , Ścisłowska-Czarnecka A.
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tom Vol. 19, no. 6 (89)
17—21
EN
The aim of the present work was to develop new composite materials based on two biocompatible polymers (sodium alginate and polycaprolactone) intended for use in the treatment of bone tissue defects. Tests carried out to obtain polymer-fibre composites using two resorbable polymers demonstrated the possibility of attaining composites with mechanical properties that are suitable from the point of view of their applications. Young’s modulus values for the composite systems analysed (254-389 MPa) are higher than for an unmodified PCL sheet. Irrespective of the fibrous phase used, the PCL matrix demonstrates stability in in vitro conditions. The constant pH values and small changes in the ionic conductance of the water indicate that these materials undergo gradual but slow degradation.
PL
W pracy opracowano warunki wytwarzania kompozytów opartych o dwa biodegradowalne tworzywa. Przeprowadzone badania wykazały zróżnicowany wpływ obecności poszczególnych rodzajów fazy włóknistej na właściwości wytrzymałościowe, właściwości fizykochemiczne powierzchni oraz stabilność materiałów kompozytowych podczas procesu inkubacji w warunkach in vitro. W oparciu o uzyskane wyniki można przypuszczać, iż wytworzone materiały kompozytowe na bazie włókien alginianowych, będących nośnikami substancji czynnych, będą powodować wytworzenie dogodnych warunków do krystalizacji apatytu w żywym organizmie.
3
Content available Chemical modification of poly ε-caprolactone with wollastonite and its influence on biological properties of osteoblast like-cells MG-63
88%
Ścisłowska-Czarnecka A. , Menaszek E. , Kołaczkowska E. , Błażewicz M. , Podporska J.
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tom Vol. 14, no. 102
11--14
EN
PCL (poly-ε-caprolactone) is a biocompatible and biodegradable polymer of aliphatic polyester group. However, PCL does not effectively bind to the bone in contrast to bioactive inorganic compounds such as wollastonite. For this wollastonite (WS) is regarded as a potential bioactive material for bone tissue engeenering although its main drawback is brittlennes. Therefore we synthesized polymer nanocomposite materials composed of poly-ε-caprolactone and wollastonite (PCL/wollastonite) containing either 0.5% or 5% of the latter modifying filler. And we aimed to verify biological properties of the nanocomposite PCL/WS materials, in comparison to the pure PCL, on cultures of osteoblast-like cells MG-63. The study revealed that the adherence of the osteoblast-like cells to the tested materials was enhanced by the PCL modification (PCL/5WS > PCL/0.5WS > PCL) while cell viability/proliferation was not altered. Furthermore, the activity of alkaline phosphatase indicative of osteoblast differentiation (maturation) was enhanced when the cells were cultured with either PCL/5WS or PCL/0.5WS. Overall, our results indicate that PCL-modified wollastonite improves biological properties of the basic biomaterial suggesting its potential usefulness/application for the bone tissue regeneration.
4
Content available Biocomatibility study of BOC polymer mesh enriched with HAp and TCP covered by PCL fibres
88%
Menaszek E. , Ścisłowska-Czarnecka A. , Draczyński Z. , Bogun M. , Stodolak-Zych E.
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tom Vol. 15, no. 116-117 spec. iss.
151--152
EN
The study was conducted in order to determine the biocomatibility of polimer mesh based on BOC and enriched with HAp or TCP coverd by PCL sub-micrometric fibres. Human osteoblast cell line NHOst was cultured in standard conditions on disk-shaped polymer samples. Interactions between materials and cells were examined through microscopic observation of cells' adhesion and morphology, and tests of viability/proliferation and cytotoxicity. The study proved the biocompatibility of all examined materials, though the surface of TCP enriched polymer didn't promote the adhesion of cells.
5
Content available Modyfikacja chemiczna kopolimeru glikolidu z epsylon-kaprolaktonem i jej wpływ na adhezję i żywotność fibroblastów in vitro
75%
Pamuła E. , Ścisłowska-Czarnecka A. , Szlęk A. , Chadzińska M. , Dobrzyński P. , Płytycz B.
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tom R. 9, nr 58-60
24-28
PL
W celu poprawienia biozgodności kopolimeru glikolidu z epsylon-kaprolaktonem (PGCap) został on zmodyfikowany poprzez inkubację przez różne okresy czasu w roztworze wodnym zasady sodowej. Zastosowana modyfikacja nie wpłynęła na chropowatość powierzchni lecz spowodowała wytworzenie tlenowych grup funkcyjnych, które nadały powierzchni charakter polarny i spowodowały obniżenie hydrofobowości. Badania in vitro wykazały lepszą adhezję i żywotność fibroblastów (L929) hodowanych na próbkach modyfikowanych powierzchniowo.
EN
Copolymer of glycolide and epsylon-caprolactone was modified by incubation in aqueous solution of sodium hydroxide for different periods of time in order to improve its biocompatibility. Applied modification did not influence surface roughness but created oxygenated functions, which enhance surface polarity and diminish hydrophobicity. In vitro studies showed better adherence and viability of fibroblasts (L929) cultivated on surface-modified samples.
6
Content available Polisiloksanowe powłoki implantów medycznych : wpływ plazmy fluorowej na skład chemiczny i właściwości polisiloksanu
75%
Szmigiel D. , Domański K. , Prokaryn P. , Grabiec P. , Pamuła E. , Ścisłowska-Czarnecka A. , Płytycz B.
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tom R. 9, nr 58-60
206-209
7
Content available Fibrous structures based of natural polymers for tissue engineering applications
75%
Stodolak-Zych E. , Ścisłowska-Czarnecka A. , Kolesinska B. , Cieślak M. , Puchowicz D. , Kaminska I. , Bogun M.
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tom Vol. 21, no. 148
63
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