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In vivo effect of 2-deoxy-D-glucose on glucose-6-phosphate dehydrogenase activity in the cytosol of liver, heart and skeletal muscle of rats

100%

Torlinska T. , Ozegowski S. , Paluszak J. , Hryniewiecki T.

Acta Physiologica Polonica

1990

tom 41

nr 7

Torlińska T., Ożegowski S., Paluszak J., and Hryniewiecki T.: In vivo effect of 2-deoxy-D-glucose on glucose-6-phosphate dehydrogenase activity in the cytosol of liver, heart and skeletal muscle of rats. Acta Physiol. Pol. 1990, 41 (6): 137-143. 2-deoxy-D-glucose (2-DG), the unmetabolizable analogue of glucose induces a series of metabolic, hormonal and behavioral responses, causing cellular glucoprivation. According to in vitro studies, 2-DG inhibits phosphofructokinase in cultured human cells. The present investigations deal with changes in the cytosolic glucocse-6-phosphate dehydrogenase activity following in vivo 2-DG administration. A single dose of 2-DG (600 mg/kg) has no influence on the activity of glucose-6-phosphate dehydrogenase in the cytosol of liver, heart and skeletal muscle of the rat. The concommitant increase in serum glucose, lactate and FFA concentrations observed in the study indicates indirectly a stimulation of adrenergic system. After three days of successive administration of 2-DG to rats, dehydrogenase activity decreased in the liver by approx 57% and in the skeletal muscle by approx 82% in comparison with control animals. Moreover the in vivo effect of 2-DG was found to be fully reversible, probably when the total amount of the inhibitor was excreted.

In vivo effect of 2-deoxy-D-glucose on adenine nucleotide levels in the liver and skeletal muscle of rats

100%

Torlinska T. , Rutkowska D. , Hryniewiecki T. , Paluszak J.

Acta Physiologica Polonica

1990

tom 41

nr 7

Torlińska T., Rutkowska D., Hryniewiecki T., Paluszak J.: In vivo effect of 2-deoxy-D-glucose on adenine nucleotide levels in the liver and skeletal muscle. Acta Physiol. Pol. 1990, 41 (7): 75-83. The present report indicates that 2-deoxy-D-glucose (2-DG) at a single dose causing reduction of Т„ has no influence on liver and skeletal muscle content of ATP, ADP and AMP, the ATP/ADP ratio, energy charge potential (ECP) and total adenine nucleotides (TAN). After administration of 2-DG for 3) successive days, the level of ATP, ATP/ADP ratio, the values of ECP and TAN are decreased both in the liver nad skeletal muscle. However, 72 hours after the last injection of 2-DG adenine nucleotide contents returned to the values observed in control group, indicating that the in vivo effect of this glucose analogue is fully reversible.

Pericardium: structure and function in health and disease

100%

Jaworska-Wilczynska M. , Trzaskoma P. , Szczepankiewicz A. A. , Hryniewiecki T.

nr 3

Kliniczne znaczenie modyfikowanej niedokrwieniem albuminy u pacjentów z zawałem mięśnia serca i prawidłowym stężeniem troponiny I

100%

Gozdzik D. , Hryniewiecki T. , Sitkiewicz D.

2007

tom 43

nr 3

High fat content in diets and oxidative stress in livers of non-diabetic and diabetic rats

88%

Marczuk-Krynicka D. , Hryniewiecki T. , Paluszak J. , Krauss H. , Nowak D.

Polish Journal of Environmental Studies

2009

tom 18

nr 2

249-253

Environmental factors such as high fat content in a diet affect pro- and antioxidative balances in tissues. Our study was designed to determine whether a four-week diet enriched to a total of 15% fat content with either a polyunsaturated (linoleic) or saturated (palmitic) fatty acid predisposes or protects the liver tissue against oxidative stress in both non-diabetic and diabetic rats. In the rat liver the activity of catalase, superoxide dismutase, glutathione peroxidase, and the level of thiobarbituric acid reactive substances were determined. Our study suggests that both diets induce oxidative stress in livers of non-diabetic rats. However, in diabetic rats a diet enriched in linoleic acid appears to attenuate oxidative stress.

Age dependent changes of insulin receptors in rat tissues

63%

Torlinska T. , Mackowiak P. , Nogowski L. , Hryniewiecki T. , Witmanowski H. , Perz M. , Madry E. , Nowak K. M.

2000

tom 51

nr 4,2