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1 Polish Journal of Environmental Studies

1 2018

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Heptoprotective role of Artemisia scoparia Waldst. and kit against CCl4-induced toxicity in rats

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Waris T. S. , Khan M. R. , Shah N. A. , Shuaib M. , Hussain F. , Ishaq M. , Kamal Z. , Zeb U. , Ali S. , Ahmed S. , Hussain F.

nr 3

In this study, the methanol extract of Artemisia scoparia was evaluated for its protective potential against carbon tetrachloride (CCl₄)-induced hepatic toxicity. Seven groups of mature albino rats were used in the course of the experiment and each group was treated with specific doses of plant extract and CCl₄. Silymarin was used as a standard protective drug. The results of the experiment revealed that Artemisia scoparia plant extract was successful in fighting CCl₄ toxicity as it clearly reduced the elevated levels of liver serum markers (alkaline phosphatase and alkaline aminotransferase), lipid peroxidation, nitrite content, and H₂O₂ on one side while enhancing the levels of antioxidant enzymes (catalase, peroxidase, superoxide dismutase, glutathione-s-transferase, γ-Glutamyltranspeptidase, and glutathione reductase) and protein content. It also protected DNA from the damaging effects of CCl₄. The findings of this study demonstrate that Artemisia scoparia plant extract plays a significant role in preventing the hepatic damages instigated with CCl₄ and can be used as a protective agent against oxidative stress-associated disorders.