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Gain-of-function complement C2 mutant as a supporter of anti-CD20 therapy in lymphoma in vitro model

100%

Urban A. , Felberg A. , Rozniak W. , Okroj M.

Acta Biochimica Polonica

2018

tom 65

nr S2

Novel properties of antimicrobial peptides

100%

Kamysz W. , Okroj M. , Lukasiak J.

nr 2

Endogenous peptide antibiotics are known as evolutionarily old components of innate immunity. Due to interaction with cell membrane these peptides cause permeabilization of the membrane and lysis of invading microbes. However, some studies proved that antimicrobial peptides are universal multifunctional molecules and their functions extend far beyond simple antibiotics. In this review we present an overview of the general mechanism of action of antimicrobial peptides and discuss some of their additional properties, like antitumour activity, mitogenic activity, role in signal transduction pathways and adaptive immune response.

In vitro analysis of the biological activity of RGD peptides and a demonstration of their in vivo ability to inhibit primary tumour growth

100%

Okroj M. , Dobrzanska Z. , Rolka K. , Bigda J.

Cellular and Molecular Biology Letters

2002

tom 07

nr Suppl.

The atypical pattern of cell death in B16F10 melanoma cells treated with TNP-470

88%

Okroj M. , Stawikowska D. , Slominska E. M. , Mysliwski A. , Bigda J.

nr 3

TNP-470 is an acknowledged anti-angiogenic factor, and was studied clinically as an anti-cancer drug. We previously reported on an additional property of this molecule: the intracellular generation of reactive oxygen species in B16F10 melanoma cells. We showed that a massive generation of ROS occurred in the first few hours after treatment with TNP-470 and that this event was critical to subsequent cell death. In this study, we analyzed the process of cell death and noticed an atypical pattern of death markers. Some of these, such as DNA fragmentation or condensation of chromatin, were characteristic for programmed cell death, while others (the lack of phosphatidylserine flip-flop but permeability to propidium iodide, the maintenance of adhesion to the substratum, no change in mitochondrial transmembrane potential, no effect of the panspecific caspase inhibitor) rather suggested a necrotic outcome. We concluded that TNP-470 induced at least some pathways of programmed cell death. However, increasing damage to critical cell functions appears to cause a rapid switch into the necrotic mode. Our data is similar to that in other reports describing the action of ROS-generating agents. We hypothesize that this rapid programmed cell death/necrosis switch is a common scenario following free radical stress.

Wymiana matek pszczelich

75%

Okroj M.

Pszczelarz Polski

1993

tom 04

nr 3