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Inhibitory topoizomerazy i - nowa klasa lekow przeciwnowotworowych.

100%

Ciesielska E.

nr 4

613-632

Porównanie systemów klimatyzacji obiektu biurowego wyposażonego w dwa typy okien

63%

Müller J. , Ciesielska E.

tom Nr 4

97--102

W artykule przedstawiono analizę techniczno-ekonomiczną dwóch systemów klimatyzacji w budynku biurowym. Uzyskano odpowiedź na pytanie, czy opłacalna jest inwestycja w droższe okna o podwyższonej refleksyjności.

In the paper the technical and economic analysis of two air-conditioning systems is presented. We were looking for the answer to the question: is it worth to invest in more expensive, reflective windows?

A rapid method of agarose gel electrophoresis for separation of different conformational forms of DNA

63%

Ciesielska E. , Szmigiero L.

Cellular and Molecular Biology Letters

1996

tom 01

nr 4

A fast two step method of agarose gel electrophoresis for separation of different conformational forms of DNA is described. In the first step the gel is run in the buffer without ethidium bromide and then the gel is stained with that dye. After staining the second step of electrophoresis is performed in the buffer without ethidium bromide. This two step procedure allows one to receive very good resolution between bands corresponding to relaxed, supercoiled, open circular, and linear forms of DNA.

Changes in activites of selected antioxidant enzymes in human erythrocytes exposed to anatoxin-A

51%

Sicinska P. , Ciesielska E. , Duda W.

nr Supplement 1

DNA-protection cross-linking induced by nitracrine in two strains of mouse lymphoma L5178Y cells

51%

Ciesielska E. , Walicka M. , Pastwa E. , Szmigiero L.

1992

tom 39

nr 1

Inhibition of mammalian topoisomerase I by 1-nitro-9-aminoacridines. Dependence on thiol activation

51%

Ciesielska E. , Pastwa E. , Szmigiero L.

nr 4

The cytotoxic activity, susceptibility to thiol activation and ability of eight 1-nitroacridine derivatives to stabilize the topoisomerase I-DNA cleavable complex, were compared. Among the acridines tested three compounds exhibited high ability to stabilize the cleavable complex. This ability was correlated with susceptibility to thiol activation as well as with cytotoxic activity. Our results suggest that 1-nitroacridine-DNA adducts interfering with topoisomerase I action may contribute to the lethal effects of some 1-nitroacridine derivatives.

DNA damage and apoptosis induction in L1210 cells by cis-diamminedichloroplatinum [II] and its new aminoflavone analogue

45%

Ciesielska E. , Studzian K. , Zyner E. , Ochocki J. , Szmigiero L.

tom 05

nr 4

441-450

This work compares the biological properties of cis-diammine- dichloroplatinum (cisplatin) and its new analogue cis-[Pt(AF)2Cl2] (AF stands for 3-aminoflavone), which contains two aminoflavone substituents as non-leaving ligands. Both compounds were tested for their antiproliferative activity against cultured L1210 cells, and their DNA interstrand crosslinking activity in cells and in a cell-free system. Cisplatin was found to be an approximately 6 times more cytotoxic drug than its new analogue. Platinum complexes reacted with purified calf thymus DNA in a cell-free system producing DNA interstrand crosslinks. The kinetics of crosslink formation was very similar for both compounds but the maximal level of crosslinks was 20% higher for cisplatin. In cells, however, crosslinks were produced by cisplatin, whereas this type of DNA lesion was almost undetected in cells treated with the aminoflavone analogue as assayed by DNA alkaline elution. At higher drug concentrations, strong degradation of DNA was observed in L1210 cells treated with cis- [Pt(AF)2Cl2] but not in the cells incubated with cisplatin. This DNA degradation seems to reflect very efficient apoptosis induction by cis-[Pt(AF)2Cl2] as the electrophoretic patterns of DNA from cells incubated with this drug showed a ladder typical for apoptotic cells.