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Biosynteza glikosfingolipidów

100%

Miller-Podraza H.

Postępy Biochemii

1984

tom 30

nr 3-4

Lack of major effects of ethanol, chlorpromazine, hexobarbital and haloperidolon brain gangliosides

80%

Miller-Podraza H. , Rakowska M. , Skarzynska E.

Acta Biochimica Polonica

1990

tom 37

nr 2

Glikosfingolipidy plemników buhaja

71%

Miller-Podraza H. , Skarzynska E. , Safianowska A. , Hryckiewicz L. , Tomaszewski L.

Medycyna Weterynaryjna

1991

tom 47

nr 04

In bull’s spermatozoons the presence of sphingosine glycolipids was verified. The neutral glycosphingolipids do not surpase 1.5 µg/10⁸ cells, gangliosides 0.2 µg/10⁸ cells. Between them quantitatively prevailed glycosylceramide (Glc-Cer) and trihexosylceramide. No one of studies compounds contained hexosamines. The bulk of acid glycosphongolipids showed the chromatographic motility typical for gangliosides GM3 (Sial-Gal-Glc-Cer). The content of glycosphingolipids of bulls spermatozoons is inconsiderable. Their role is still obscure. There is a need for further research aimed at the elucidation of their biological function.

Epitope dissection of receptor-active gangliosides with affinity for Helicobacter pylori and influenza virus

61%

Miller-Podraza H. , Larsson T. , Nilsson J. , Teneberg S. , Matrosovich M. , Johansson L.

Acta Biochimica Polonica

1998

tom 45

nr 2

Receptor-active gangliosides with affinity for Helicobacter pylori and influenza virus were chemically modified and analyzed by negative ion fast atom bombardment mass spectrometry (FAB MS) or electron ionization mass spectrometry (EI MS) after permethylation. Derivatizations included mild periodate oxidation of the sialic acid glycerol tail or conversion of the carboxyl group to primary alcohol or amides. The modified gangliosides were then tested for binding affinity using thin-layer plates overlaid with labeled microbes or microbe-derived proteins. Mild periodate oxidation, which shortens sialic acid tail without destruction of sugar cores, abolished or drastically reduced binding of H. pylori and avian influenza virus to sialyl-3-paragloboside (S-3-PG). The same effect was observed in the case of binding of the human influenza virus to receptor-active gangliosides of human leukocytes. Conversion of S-3-PG or leukocyte gangliosides to primary alcohols or amides also abolished the binding. However, mild periodate oxidation had no effect on binding of NAP (neutrophil-activating protein of H. pylori) to the active ganglioside.