Wyniki wyszukiwania - Biblioteka Nauki

1

Disturbed angiogenic activity in sera from obstructive sleep apnea patients

100%

Chorostowska-Wynimko J. , Radomska D. , Plywaczewski R. , Jonczak L. , Stepniewska A. , Gorecka D. , Skopinska-Rozewska E.

Journal of Physiology and Pharmacology. Supplement

|

2005

|

tom 56

|

nr 4

71-77

EN

It is increasingly recognized that obstructive sleep apnea (OSA) syndrome is a systematic rather than local disorder. There is also growing evidence that apart from the syndrome's major features: intermittent hypoxia and sleep fragmentation, functional activity of the immune system is altered in OSA patients, with several cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) taking active part in sleep regulation. Little is known about the effects exerted by chronic intermittent hypoxia combined with persistent pro-inflammatory activity of the immune system on the vascular micro milieu in OSA. In this study we attempted to confirm the hypothesized imbalance between pro- and anti-angiogenic factors by evaluating direct and indirect angiogenic activity of OSA patients' sera in the in vivo serum-induced angiogenesis (SIA) and leukocyte-induced (LIA) assays, respectively, in mice. Both tests revealed significantly inhibited angiogenic activity of OSA patients' sera compared with healthy controls (P<0.001). Moreover, differences related to the subject’s weight regarding in the mean number of newly-formed vessels were observed with a significantly greater inhibition in the normal-weighing apneic subjects than in the overweight or obese ones (P<0.01). The angiogenesis inhibition index was positively related to the serum IL-6 level (r=0.35; P<0.05) in the OSA group, but not to TNF-alpha, fasting serum leptin, or OSA syndrome severity as assessed by the AHI index. Our results demonstrate that OSA is accompanied by disturbed serum angiogenic activity, apparently resulting from an imbalance between pro- and anti-angiogenic factors, some of them being produced by the adipose tissue. The disordered angiogenic activity might be related to the pathophysiology of OSA and should be considered an important causative factor for the increased prevalence of cardiovascular diseases in OSA patients.

2

Effect of extracts of St. John's wort (Hypericum perforatum L.) and lemon balm (Melissa officinalis L.) herbs on local GvH reaction and production of anti-SRBC antibodies

100%

Skopinska-Rozewska E. , Rzadkowska-Bodalska H. , Olechnowicz-Stepien W. , Zukowska M. , Malkowska-Zwierz W. , Radomska D. , Sobczynska A.

Bulletin of the Polish Academy of Sciences. Biological Sciences

|

1991

|

tom 39

|

nr 3

3

The effect of Tolpa peat preparation [TPP] on human mononuclear leucocytes induced angiogenesis

84%

Skopinska-Rozewska E. , Polakowski I. , Zukowska M. , Radomska D. , Malkowska-Zwierz W. , Demkow U. , Skopinski P. , Pazdur J. , Liszewska-Pfeifer D.

Herba Polonica

|

1993

|

tom 39

|

nr 1-2

41-51

EN

TPP enhanced the ability of nonactivated human mononuclear leucocytes (MNC) derived from the blood of young and aged donors, patients with coronary artery disease and patients with oral candidiasis, to induce neovascularization in the local graft versus host (GvH) reaction (H-LIA assay), diminished high activity of lymphocytes from rheumatoid artritic patients, but not influence the response of MNC of diabetic patients with proliferative retinopathy. Various fractions of mononuclear leucocytes were grafted intradermally into immunosuppressed (with cyclophosphamide) Balb/c mice. Recipients were then treated with PTT or saline. After 3 days the local GvH reaction was evaluated as the mean number of newly formed blood vessels surrounding the cell graft sites. CD4+ and CD8+ theophylline sensitive Fcy+ lymphocytes and monocytes responded to PTT by significant enhancement of their angiogenic activity.

PL

Oceniano wpływ TPP na aktywność angiogenną ludzkich leukocytów jednojądrzastych krwi obwodowej (MNC). Stwierdzono, że PTT stymuluje uwalnianie czynników angiogennych powodujących tworzenie się naczyń krwionośnych przez komórki MNC pochodzące od zdrowych dawców oraz od pacjentów ze schorzeniami geriatrycznymi, z chorobą niedokrwienną serca oraz pacjentów z kandydozą jamy ustnej, u których początkowa aktywność angiogenna jest obniżona. PTT obniża także patologicznie wysoką aktywność angiogenną komórek MNC pochodzących od pacjentów z reumatoidalnym zapaleniem stawów, ale nie zmienia takiej aktywności w przypadku komórek pochodzących od pacjentów z retinopatią cukrzycową. Komórkami odpowiadającymi na TPP są: monocyty Fcy+ oraz limfocyty Fcy+, CD4+ i CD8 + wrażliwe na teofilinę.

4

The effect of vitamin E on granulocyte function in patients with recurrent infections

67%

Malkowska-Zwierz W. , Garlinski P. , Zukowska M. , Zabuska K. , Wartanowicz M. , Kleniewska D. , Niemirowska H. , Izdebska Z. , Roszkowski W. , Wroblewski T. , Ziemlanski S. , Radomska D. , Skopinska-Rozewska E.

Archivum Immunologiae et Therapiae Experimentalis

|

1991

|

tom 39

|

nr 1-2