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3 International Letters of Chemistry, Physics and Astronomy

3 2015

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Synthesis and Antimicrobial Screening of 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo[1, 2-a]pyridine -3-yl]-6"-aryl-4"-H-pyran-3"- Carbonitrile

100%

Bhuva V. V. , Bhadani V. N. , Purohit H. D. , Purohit D. M.

International Letters of Chemistry, Physics and Astronomy

2015

tom Vol. 49

149--154

3-Cyano-4,6-disubstituted 4H-pyrans are endowed with a variety of pharmacodynamic activities Looking to the interesting properties of cyanopyrans, it was considered worthwhile to synthesis some new 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo [1,2-a] pyridin-3-yl]-6"-aryl-4"-H-pyran-3"- carbonitrile ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/mL. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.

Synthesis, Spectral Studies Antibacterial and Antifungal Activity of 2" – Amino - 4" - [2 - (4' -chlorophenyl)-6-methyl imidazo[1, 2-a] pyridin-3-yl]-6"-aryl Nicotinonitrile

100%

Bhuva V. V. , Bhadani V. N. , Purohit H. D. , Purohit D. M.

International Letters of Chemistry, Physics and Astronomy

2015

tom Vol. 49

161--166

Pyridine nucleus plays an important role in medicine, agriculture and industrial chemistry. With a view of biological activities and variety of industrial applications, some new 2" – amino - 4" - [2 - (4' -chlorophenyl)-6-methyl imidazo [1, 2-a] pyridin-3-yl]-6"-aryl nicotinonitriles ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/ml. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.

Synthesis and Antimicrobial Activity of 2-{4'-[(6"-aryl)2"-hydroxy-3",4"-dihydro-pyrimidine-4"-yl]-phenyl amino}-6-[bis (2'"-chloroethyl) amino]-4-Methoxy-1,3,5-Triazine

100%

Kathiriya P. J. , Purohit H. D. , Purohit D. M.

International Letters of Chemistry, Physics and Astronomy

2015

tom Vol. 49

137--142

The titled compounds (5a-5k) have been synthesized by the condensation of 2-{4'-[(3"-aryl)-2"-Propene-1"-one]-Phenyl amino}-6-[bis-2""-chloroethyl) amino]-4-methoxy-1,3,5-triazine with urea in presence of conc. HCl (0.3ml) The biological activities of these compounds have been examined against various Gram +ve, Gram –ve bacteria and fungi. The structure of the products was confirmed by IR, 1H NMR, Mass spectra and elemental analysis.