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The immunity in Toxoplasma gondii infections

100%

Dlugonska H.

Postępy Higieny i Medycyny Doświadczalnej

2000

tom 54

nr 1

52-66

The immunity in Toxoplasma gondii infections The article presents selected data concerning pathogenesis, clinical manifestations, natural and specific resistance and vaccines against T. gondii infections. Toxoplasma gondii protozoan has been recognized as one of the most successful parasites infecting any nucleated cell of human individuals and most warm-blooded animals. The infection causes life-threatening disease in individuals with defective immunity such as fetuses, AIDS patients and transplant recipients. In immunocompetent humans toxoplasmosis is usually asymptomatic. Following an acute phase of infection characterized by systemic spread of rapidly dividing tachyzoites, bradyzoites encyst in various host tissues (brain, muscles) and may persist there lifelong. Toxoplasmosis in controlled by vigorous cell-mediated immune response capable of killing infected cells and parasites. As shown in the mouse experimental model natural killer cells (NK) are critical for the resistance at the early stage of primary infections, whereas adaptive immunity depends on T lymphocytes. Both CD4+ Th1 and CD8+ Tc1 lymphocytes are believed to mediate protection by producing of IFN-?, a pitoval cytokine that induces anti-Toxoplasma effector mechanisms in macrophages.

Mouse recombinant interleukin 2 ? determining optimal conditions of production and activity evaluation in vitro

63%

Krzyminski P. , Dlugonska H.

Biotechnologia

2004

nr 1

284-290

Interleukin 2 (IL-2) is the fundamental growth factor for T lymphocytes, both in vivo and in vitro. At our department, specific mouse T lymphocyte clones are used for the examination of antigenic structure of Toxoplasma gondii. Their culturing in vitro requires big amounts of IL-2. That is why we determined optimal conditions for producing crude IL-2 preparation, using recombinant myeloma line X63/0 IL-2 as the producer of IL-2 and cytotoxic lymphocyte line CTL-L as the indicator of IL-2 activity.