Wyniki wyszukiwania - Biblioteka Nauki

1

Multiple myeloma - interdiscipline diagnostic problem

100%

Gorska M. , Jawniak D. , Hus I. , Horobowska J.

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EN

Multiple myeloma (MM) is an uncurable plasma cell malignancy, with incidence approximately 4 per 100 000 population and rich symptomatology causing often significant diagnostic problems. In 1992-2004 in Haematology Department of Medical University in Lublin MM was diagnosed in 197 patients (110 woman and 87 men, mean age 61± 11.2 years). The most common monoclonal protein type of was IgG, detected in 133 patients. At the time of initial diagnosis in 138 patients bone pain was a main complain, in 10,2% of these patients it was caused by pathological fractures. In 20 patients (10.2%) clinical course was indolent, and disease was diagnosed accidentally. In the other patients first clinical manifestation were unspecific symptoms, such as: general weeknes (15/197 patients), paraparesis (9/197), acute renal failure (8/197), prolonged infections (8/197) bone of soft tissue tumours (7/197). Taking into account unspecific clinical picture preliminary diagnostics should focus on characteristic for MM laboratory features, i.e.: highly accelerated erythrocyte sedimentation reaction resulted from hyper- and para-proteinaemia; proteinuria; osteolytic lesions in bone radiograms. Lack of appropriate diagnostic strategy prolongs time to therapy commencement to 5.3±4.7 months, in some cases even to 24 months. On the level of basic health care total protein serum level and bone radiograms are adequate diagnostic investigation to establish preliminary diagnosis of MM. In our study increase of total protein serum level and characteristic changes in bone radiograms were found in 96% of patients.

2

Cytokine production in whole blood cell cultures of patients with B-lineage acute lymphoblastic leukemia. The influence of granulocyte-macrophage colony-stimulating factor

100%

Kaminska T. , Hus I. , Dmoszynska A. , Kandefer-Szerszen M.

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nr 1

3

Mechanizmy immunologiczne w nowotworach i proby wykorzystania ich w immunoterapii

88%

Kawiak J. , Hus I. , Rolinski J. , Hoser G. , Dmoszynska A.

Postępy Biologii Komórki. Suplement

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2004

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tom 22

67-77

4

Effect of granulocyte colony stimulating factor treatment on ex vivo cytokine production by blood cells of patients after chemotherapy or radiotherapy

88%

Kaminska T. , Dmoszynska A. , Hus I. , Croneck A. W. , Kandefer-Szerszen M.

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nr 1

5

TLR2 expression on leukemic B cells from patients with chronic lymphocytic leukemia

75%

Szymanska A. , Bojarska-Junak A. , Drobiecki A. , Tomczak W. , Rolinski J. , Hus M. , Hus I.

Archivum Immunologiae et Therapiae Experimentalis

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2019

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tom 67

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nr 1

6

Interferon production by peripheral blood leukocytes of patients with acute myeloid leukemia

75%

Kandefer-Szerszen M. , Dmoszynska A. , Borowska L. , Adamczyk-Cioch M. , Hus M. , Hus I. , Rolinski J.

Archivum Immunologiae et Therapiae Experimentalis

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1996

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tom 44

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nr 2-3

7

Interferon gamma as immunomodulator in a patient with multiple myeloma

75%

Kaminska T. , Dmoszynska A. , Cioch M. , Hus I. , Jawniak D. , Szuster-Ciesielska A. , Kandefer-Szerszen M.

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nr 2

8

Assessment of the pathway of apoptosis involving PAR-4, DAXX and ZIPK proteins in CLL patients and its relationship with the principal prognostic factors

63%

Bojarska-Junak A. , Sieklucka M. , Hus I. , Wasik-Szczepanek E. , Kusz M. L. , Surdacka A. , Chocholska S. , Dmoszynska A. , Rolinski J.

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tom 49

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nr 1

9

ZAP-70 and CD38 expression are independent prognostic factors in patients with B-cell chronic lymphocytic leukaemia and combined analysis improves their predictive value

63%

Hus I. , Bojarska-Junak A. , Dmoszynska A. , Wasik-Szczepanek E. , Sieklucka M. , Trzesniewska W. , Glazer M. , Rolinski J.

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nr 2

147-152

10

BIAL - Registration and Monitoring System for Patients with chronic lymphocitic leukemia

63%

Ładyżyński P. , Migalska-Musiał K. , Foltyński P. , Kawiak J. , Hus I. , Sieklucka M. , Roliński J. , Dmoszyńska A. , Wójcicki J. M.

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tom Vol. 25, no. 3

57-63

EN

B-cell chronic lymphocitic leukemia (B-CLL) is the most common type of leukemia in adults. The aim of the work was to design and implement a computer registration and monitoring system for patients with B-CLL. The developed BIAL system comprises modules allowing for registration of the data related to patient's identification, patient's general state (e.g. objective examination, phenotype, etc.), laboratory examinations (biochemical, immunological and cytogenetical), applied treatment (chemo- and/or immunotherapy) and evaluation of immunotherapy on an animal model. Selected biochemical and immunological parameters can be presented on charts, to facilitate evaluation of patient's state, the course and outcome of the treatment. The BIAL system was preliminary verified basing on the data registration of 8 B-CLL patients treated with chemo- or immunotherapy in the Clinic of Hematooncology and Bone Marrow Transplantation MU in Lublin. It was found to be comprehensive yet easy to learn and use. The system should facilitate the current treatment of the B-CLL patients and should make a foundation for the future multi-patients data analysis leading to elaboration of the criteria for selection of the optimal treatment regimen for patients with B-CLL.

11

CD3plus/CD16plusCD56plus cell numbers in peripheral blood are correlated with higher tumor burden in patients with diffuse large B-cell lymphoma

51%

Hus I. , Staroslawska E. , Bojarska-Junak A. , Dobrzynska-Rutkowska A. , Surdacka A. , Wdowiak P. , Wasiak M. , Kusz M. , Twardosz A. , Dmoszynska A. , Rolinski J.

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tom 49

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nr 1