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1
Modulatory effect of VIP injected into hippocampal CA1 area on anxiety in olfactory bulbectomized rats
100%
Ivanova M. , Belcheva S. , Stoyanov Z. , Tashev R.
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nr 3
EN
Vasoactive intestinal peptide (VIP) is a neuropeptide, which is widely distributed in the central nervous system and peripheral tissues, acting both as a neurotransmitter and neuromodulator. Despite its extensive expression in the hippocampus, amygdala and other limbic system structures, the effects of VIP on anxiety and depression have not yet been fully investigated. The aim of the present study was to evaluate the involvement of VIP and VIP receptors in the mechanism of anxiety in rats with a model of depression (bilateral olfactory bulbectomy), using the elevated plus-maze test. VIP and a non-specific antagonist of VIP receptors (VIP6-28) were administered unilaterally into the hippocampal CA1 area of bulbectomized (OBX) rats. VIP (10 ng) showed a tendency for an anxiety-modulatory effect upon right side injection, by reducing significantly the closed arm time and increasing the open arm time. VIP (100 ng) injected unilaterally (left or right) into CA1 area induced an anxiolytic-like effect on the activity of OBX rats (increased the number of open arms entries, open arm time and the ratio open/total number of entries).VIP6-28 failed to antagonize the anxiety-related behavior of OBX rats in the plus maze. An unexpected finding in our study was that upon pretreatment with VIP6-28, VIP (10 ng), injected unilaterally (left or right) exerted an anti-anxiety like effect (increased the number of open arm entries, open arm time and the ratio open/total number of entries). Our data point to a possible involvement of hippocampal VIP-ergic neurons in modulating emotional processes or adaptive responses to stressful stimuli in a rat model of depression.
2
Study on the role of a sperm membrane-associated antigen in canine fertilization
88%
Mollova M. , Ivanova M. , Atanasov B. , Petrov M. , Kuyrkchiev S.
Reproductive Biology
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2005
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tom 05
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nr 3
3
Content available Forecasting of the productivity of parts machining by highspeed milling with the method of half-overlap
88%
Dobrotvorskiy S. , Basova Y. , Ivanova M. , Kotliar A. , Dobrovolska L.
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tom Vol. 19, No. 3
37--42
EN
In the article the technology of high-speed milling was observed as a key to the most promising methods of engineering products machining. It is indicated that the correct choice of the strategy for moving the cutting tool in the manufacture of products is the basis for ensuring the desired surface quality of the workpiece and its high processing efficiency. A review of the work devoted to the diagnosis of high-speed processing strategies was performed. Based on the up-to-date knowledge of the physics of the process of establishing of a qualitative surface, the article proposes to consider a new technology of high-speed milling with half-overlap. As the main idea of this technology, it is suggested to consider the work of the deformation component of cutting process as the main component of the complex energy-intensive process of high-speed milling. In addition, the paper suggests a technique for estimating the productivity of machining by the method of high-speed milling with half-overlap. It is theoretically justified that the specific productivity of the proposed technology is quite high Q=12.5÷4.2 cm2 /min and depends on the technological regimes. The place of technology of high-speed milling with half-overlap in the technological process of manufacturing details of any complexity was noted. The area of further research is indicated.
4
Content available Effects of γ-irradiation of wild thyme (Thymus serpyllum L.) on the phenolic compounds profile of Its ethanolic extract
75%
Janiak M. A. , Slavova-Kozakova A. , Kancheva V. D. , Ivanova M. , Tsrunchev T. , Karmac M.
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tom 67
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nr 4
EN
The presented study revealed that there were changes in the phenolic compounds profile of extract of wild thyme (Thymus serpyllum L.) after γ-irradiation at the dose of 5 kGy. Ethanolic extracts of irradiated and non-irradiated herb were prepared and their compounds were analyzed by RP- -HPLC-DAD technique. Between thirty two detected constituents, twelve phenolic compounds classifi ed as hydroxybenzoic and hydroxycinnamic acids derivatives, flavones and flavanones were identifi ed. Among them, caffeic acid derivatives and flavones predominated with the highest content of rosmarinic acid and luteolin-7-O-glucoside, respectively. Additionally, thymol was recognized in the analyzed extracts. γ-Irradiation slightly affected the quantitative profile of phenolic compounds of a wild thyme ethanolic extract. Only four constituents differed signifi cantly (P<0.05) in terms of their content in the irradiated and non-irradiated samples. The content of phenolic acids (p-coumaric and caffeic acids) decreased and that of flavonoid aglycons (luteolin and eriodictyol) increased after the γ-ray treatment.
5
Immunolocalization and binding characteristics of boar seminal plasma glycoprotein [Gp-54] and its component - the sperm motility factor [SMIF]
75%
Kordan W. , Mollova M. V. , Ivanova M. , Holody D. , Georgieva R. , Strzezek J.
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tom 17
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nr 2
49-57
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