Wyniki wyszukiwania - Biblioteka Nauki

1

The principles of plant selection in gardens designed by Eduard Petzold (1815-1891)

100%

Jaworek J.

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tom R. 111, z. 6-A

225--238

EN

Eduard Petzold is regarded as one of the most important German landscape garden art designers and theoreticians of the second half of the 19th century. He founded 'Arboretum Muscaviense' at Bad Muskau, which was very popular in the 19th century. His interest in dendrology was reflected in his garden designs. His garden plans included detailed plant selection guidelines. In Lower Silesia, 15 original plans survive, and so it is possible to investigate Petzold’s garden craft. This paper is aimed at raising awareness of the greenery composition principles applied by Eduard Petzold and at studying the surviving tree stands created in line with his recommendations in present-day parks.

PL

Eduard Petzold zaliczany jest do grona najważniejszych niemieckich projektantów i teoretyków krajobrazowej sztuki ogrodowej 2 połowy XIX wieku. Był założycielem słynnego w XIX wieku "Arboretum Muscaviense" w Bad Muskau. Jego zainteresowania dendrologiczne znalazły odzwierciedlenie w projektach ogrodów, w których zawarł szczegółowe informacje na temat doboru roślin. Na terenie Dolnego Śląska zachowało się 15 takich oryginalnych projektów, dzięki którym możliwe jest poznanie warsztatu ogrodniczego Petzolda. Celem pracy jest podniesienie wiedzy na temat zasad komponowania zieleni, stosowanych przez Eduarda Petzolda, a także rozpoznanie obecnego stanu zachowania parków i form zadrzewień, wprowadzonych według jego zaleceń.

2

Wykorzystanie metod przetwarzania obrazów w rozpoznawaniu i diagnostyce czerniaka złośliwego

100%

Jaworek J.

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tom R. 15, nr 12

100-101

PL

Czerniak złośliwy jest jednym z najszybciej rozwijających się nowotworów skóry, a zachorowalność na niego stale wzrasta. Podstawowym badaniem nieinwazyjnym pozwalającym na jego rozpoznanie jest dermatoskopia. Celem badania dermatoskopowego jest diagnostyka różnicowa zmian barwnikowych z podziałem na zmiany melanocytowe i niemelanocytowe. Badanie pozwala odróżnić zmiany melanocytowe, wymagające wycięcia chirurgicznego oraz badania histopatologicznego, od zmian łagodnych. Szybki rozwój elektroniki i informatyki pozwolił na wyodrębnienie dwóch nowych dziedzin w dermatoskopii (foto- i wideodermatoskopii), które umożliwiają cyfrowy zapis zdjęć. Komputerowa analiza obrazów dermatoskopowych polega na ocenie poszczególnych zmian, określaniu ich zaawansowania i wyznaczaniu podstawowych parametrów diagnostycznych (określanie barwy, ilości barw, rozmiaru, symetrii oraz struktur różnicujących). Badania komputerowe wykazują dużą skuteczność, jednak nie są zalecane jako jedyny sposób oceny zmian. Obecne systemy nie ograniczają niepotrzebnych zabiegów chirurgicznych, co uznawane jest za ich podstawową wadę. Wymagany jest dalszy rozwój aplikacji oraz opracowanie nowych, nowatorskich rozwiązań, aby dermatoskopia wspomagana komputerowo stała się wiodącą metodą diagnostyczną.

EN

Skin melanoma is one of the most malignant tumours and increasing melanoma incidence rate has been observed worldwide in the last several years. Due to high skin cancer incidence, dermatologic oncology has become a quickly developing branch of medicine. Dermoscopy is the most common and non-invasive method to diagnose skin cancer. The aim of dermoscopy is to dif erentiate malignant melanoma from other lesions of the skin (hemangiomas and nevi) as well as preliminary staging and malignancy assessment. It is possible to distinguish malignant tumours, requiring surgical removal followed by histopathological examination, from benign changes. The rapid development of electronics and information technologies enabled to create two new areas of dermoscopy (photo- and videodermoscopy) that use digital imaging for storing the data. The aim of computer systems in dermoscopy is to analyse each image and to evaluate each change, identifying them and determining the advancement of basic diagnostic parameters (determination of colour, border, size, asymmetry and dif erential structures). Recent studies of software systems show high ei ciency, but it is still not recommended that the software systems are the only one to evaluate the changes. Rapid development of medical equipment and computer systems for medical applications gives hope for better and faster diagnoses of malignant melanoma and that dermoscopy image processing will become a leading diagnostic method.

3

Rola społeczeństwa w ochronie i zarządzaniu krajobrazem na przykładzie Caerlaverock i Langholm and Newcastleton Hills w południowej Szkocji

100%

Jaworek J.

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tom nr 10

592--599

4

Rola społeczeństwa w ochronie i zarządzaniu krajobrazem na przykładzie Caerlaverock i Langholm and Newcastleton Hills w południowej Szkocji

100%

Jaworek J.

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2008

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nr 10

5

Central and peripheral control of pancreatic integrity by leptin and melatonin

100%

Jaworek J.

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tom 52

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nr 2

6

Image processing application for enhancement of medical diagnostic features

63%

Jaworek J. , Kańtoch E.

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tom Vol. 4, no. 7

51--55

EN

Automatic analysis of medical imaging is the permanently developed discipline requiring the interdisciplinary collaboration linking medicine and computer science. The technique oriented on the increasing the resolution of the medical images is presented.

7

Effects of prostaglandin of E, F and I series, leukotriene C4 and platelet activating factor on amylase release from isolated rat pancreatic acini

63%

Jaworek J. , Konturek S. J.

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nr 4

8

Neural networks for medical image processing

51%

Pieciak T. , Jaworek J. , Gorgon M.

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2011

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tom Vol. 7, no. 4

101--110

EN

The proposed article presents the most common types of artificial neural networks used to be performed in the field of medical imaging. The first section describes the use of artificial neural networks in the preprocessing stage, restoration of noisy and distorted images and in conjunction with morphological operations. The second part presents the artificial neural networks in image segmentation problem, particularly in adaptive binarization threshold level selection and as a complement to the active contour method.

9

Zmiana powierzchni zbiorowisk o charakterze leśnym w dolinie Karpnickiego Potoku jako przykład zmian lesistości w dolnych partiach Sudetów

51%

Jaworek J. , Filipiak M. , Napierala-Filipiak A.

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nr 09

EN

On the basis of historical and recent cadastral maps, topographic maps, and aerial photographs, we analysed changes in forest area within the cadastral units of Karpniki village, in the Karpnicki Potok (SW Poland). In 1823−2012, forest area increased there from about 41% to over 57% of the total area. The greatest increase has been recorded recently. Moreover, at that time over 16% of land classified officially as farmland was naturally colonized by communities dominated by woody plants. This seminatural process in the analysed case does not pose any serious threat to natural resources, but a complete lack of its control may lead to deterioration of the value of the local landscape and development of low−quality forest stands. The observed changes seem to be typical of other areas located in lower parts of the Sudety Mountains.

10

Inżynieria biomedyczna w projektach studenckich KN IMPLANT

51%

Panek D. , Długosz M. , Jaworek J. , Izworski A.

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tom R. 15, nr 12

252-254

PL

Członkowie KN IMPLANT w ramach pracy naukowej realizują ciekawe projekty, proponując innowacyjne rozwiązania problemów na pograniczu informatyki, telemedycyny i innych dziedzin techniki związanych z medycyną. W artykule opisano kilka z nich, prezentując dwa projekty zaplanowane na najbliższy rok.

EN

Scientific Circle of Bioengineering IMPLANT IEEE EMBS Student Club Poland (abbreviation SC IMPLANT) was founded in 1984. It is an interdepartmental organization that brings together students from different fields and specialties, interested in bioinformatics, medical physics, telemedicine and other areas of biomedical engineering. SC IMPLANT members in their scientific work have implemented many interesting projects, proposing innovative solutions for biomedical engineering. The main aim of the SC Implant is to realize collaborative projects, exchange ideas and experiences on bioengineering, prepare workshops and university events, meet invited professionals. The authors described in this paper two projects that were already realized and two proposed for the next few years.

11

Krajobraz doliny Karpnickiego Potoku. Zastosowanie systemów GIS w analizach historycznych krajobrazu

51%

Jaworek J. , Gołuch P. , Michalski A.

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2010

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tom nr 1

55--61

EN

The river and brook valleys of the Sudeten Mountains have played an important role in developing the area. Along the rivers there has formed a characteristic settlement landscape inextricably linked to the hydrographic network. Recent years have seen further transformations of the riverine areas, which has led to the disappearance of many historical landscape components. This raises questions about the nature of the present changes. The article is an attempt to present the dynamism of transformations of the Karpnicki Brook Valley landscape. A comparison of conditions from 1938,1994 and 2004, has enabled the authors to determine the landscape development trends and to establish goals for the protection of the historical architectural-and-landscape composition. The analysis has been conducted using aerial photographs as the source material; thanks to this, it has been possible to obtain a comprehensive picture of changes to spatial relationships. The photos were used to make digital orthophotos, which then constituted the basis for developing maps in GIS. The maps made it possible to compare the condition of the landscape at various points in time.

12

Increase of heat shock protein gene expression by melatonin in AR42J cells

51%

Bonior J. , Jaworek J. , Konturek S. J. , Pawlik W. W.

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nr 3

EN

Heat shock proteins (HSPs) have been reported to protect the pancreatic cells from the acute damage produced by caerulein overstimulation. However the effects of caerulein, melatonin or hyperthermia preconditioning on mRNA signal for HSP60 in the pancreatic acinar cells has not been examined yet. The aims of this study were: 1. To investigate the gene expression for HSP60 in the pancreatic AR42J cells stimulated by melatonin, caerulein or combination of both these substances. 2. To compare above changes with mRNA signal for HSP60 in pancreatic AR42J cells subjected to hyperthermia preconditioning. AR42J cells were incubated in standard medium at 37°C for: 0, 1, 3, 5, 12 or 24 h, under basal conditions. Above cells were then subjected to heat shock (42°C) for 0, 1 or 3 h. In the next part of the study AR42J cells were incubated in presence of caerulein (10-11, 10-9 or 10-7M), melatonin (10-8 or 10-6M), or combination of above under basal conditions or following heat shock pretreatment. Gene expression for HSP60 was determined by RT-PCR. The mRNA signal for HSP60 has been observed in AR42J cells under basal conditions, and this signal was markedly and time-dependently increased in these cells subjected to hyperthermia preconditioning. Incubation of AR42J cells in presence of melatonin (10-8 or 10-6M) resulted in the significant and dose-dependent increase of gene expression for HSP60 in both groups of AR42J cells: preconditioned and in those, which were not subjected to hyperthermia. Caerulein stimulation reduced mRNA signal for HSP60. The strongest signal has been observed after the exposition of AR42J cells to hyperthermia preconditioning, combined with melatonin and caerulein. We conclude that: 1. Gene expression for HSP60 has been detected in pancreatic AR42J cells under basal conditions. 2. Hyperthermia preconditioning resulted in a significant and time-dependent increase of HSP60 signal in pancreatic AR42J cells. 3. HSP60 gene expression was significantly increased in pancreatic AR42J cells stimulated by melatonin whereas caerulein reduced this signal. 4. The strongest gene expression for HSP60 has been found in the cells subjected to the combination of hyperthermia preconditioning, caerulein and melatonin.

13

Effects of ammonia and alkalization on secretory activity of isolated rat pancreatic acini

51%

Jaworek J. , Jachimczak B. , Konturek S. J.

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nr 1

14

Interleukin-25, thymic stromal lymphopoietin and house dust mites in pathogenesis of atopic dermatitis

45%

Jaworek A. K. , Szafraniec K. , Zuber Z. , Wojas-Pelc A. , Jaworek J.

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nr 2

15

Only live Helicobacter pylori is capable of caspase-3 dependent apoptosis induction in gastric mucosa epithelial cells

45%

Pierzchalski P. , Pytko-Polonczyk J. , Jaworek J. , Konturek S. J. , Gonciarz M.

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nr 4

119-128

EN

Physiological process of cell death, apoptosis, plays a beneficial role in organism survival, but in some pathologies, like gastric Helicobacter pylori (Hp) infection, this process may turn against the host organism causing tissue damage. Knowledge of the mechanisms controlling apoptosis may have potential significance in treatment of these pathologic states. Therefore, we sought to determine whether apoptosis induced in the gastric epithelial cells exposed to live Hp involves the alteration in heat shock protein 70 (HSP70) expression and activation of caspase-3 in peroxisome proliferator-activated receptors (PPARg dependent manner). Experiments were performed with KATO III, gastric epithelial cells, exposed to CagA and Vac A positive live Hp , water Hp extracts or Hp culture supernatant over different time periods. Total cellular RNA and proteins were isolated for PCR, western-blot and EMSA studies. Genomic DNA was isolated to analyze apoptosis status. We propose new model of Hp induced HSP70 dependent, caspase-3 executed apoptosis in human gastric epithelium. KATO III cells exposed to Hp , showed an increase in caspase-3 activity accompanied and preceeded by activation of nuclear translocation of PPAR peaking at 48 h of culture. Moreover, heat shock factor 1 (HSF-1) bound up with phosphorylated STAT-3 was unable to activate HSP70 protein synthesis in KATO III exposed to Hp . Lack of protective effect of HSP70, activation of caspase-3 - dependent apoptosis pathway caused by Hp and alteration of the bax/bcl-2 cellular equilibrium led to gastric epithelial cell death. The observed phenomenon might be helpful in understanding of the mechanism of Hp related gastrointestinal tract diseasess, especially gastric cancer.

16

Leptin is able to stimulate pancreatic enzyme secretion via activation of duodeno-pancreatic reflex and CCK release

38%

Nawrot-Porabka K. , Jaworek J. , Leja-Szpak A. , Palonek M. , Szklarczyk J. , Konturek S. J. , Pawlik W. W.

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nr 2

47-57

EN

Leptin, 16- kDa protein produced and secreted from white adipocytes is known to regulate food intake and energy expenditure. Leptin receptors have been detected in the pancreas and it has been shown that systemic application of this protein diminished postprandial pancreatic secretion. Leptin is also produced in the stomach and released into the gastrointestinal lumen but the implication of luminal leptin in the regulation of pancreatic enzyme secretion has not been elucidated. The aim of our study was to evaluate the effects of intraduodenal (i.d.) leptin administration on pancreatic enzyme secretion and to assess the involvent of afferent nerves and CCK in above effects. The secretory studies were carried out on anaesthetized Wistar rats with acute pancreatic fistulae. Leptin was administered to the animals at doses of 0.1 1.0 or 10.0 µg/kg i.d. Tarazepide (2.5 mg/kg i.d.), a CCK1 receptor antagonist, was given to the rats prior to the application of leptin. Rats with capsaicin deactivated sensory nerves were used in part of the study. Samples of pancreatic juice were taken at 15 min intervals to measure the volume flow and protein and amylase concentrations. CCK plasma level was measured by radioimmunoassay (RIA) following administration of leptin to the rats. Intraduodenal administration of leptin (1.0 or 10.0 µg/kg) to the fasted rats significantly and dose-dependently increased pancreatic protein and amylase outputs. Pancreatic secretory responses to leptin were totally abolished by prior capsaicin deactivation of sensory nerves or by pretreatment of the rats with tarazepide. Under basal conditions plasma CCK level averaged about 15.46 ± 1,4 pg/ml. Exogenous leptin, given i.d. at doses of 0.1 1.0 or 10.0 µg/kg i.d. to the rats with intact or capsaicin-deactivated sensory nerves resulted in dose-dependent rise of plasma CCK level, reaching the highest value at the dose of 10.0 µg/kg i.d. We conclude that leptin given i.d. stimulates pancreatic enzyme secretion and this effect could be related to the stimulation of CCK release and activation of duodeno-pancreatic reflexes.

17

The effects of ammonia on pancreatic enzyme secretion in vivo and in vitro

38%

Jaworek J. , Bilski J. , Jachimczak B. , Cieszkowski M. , Kot M. , Bielanski W. , Konturek S. J.

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nr 2

18

Role of tachykinins in the control of pancreatic secretion and circulation

38%

Pawlik W. W. , Konturek S. J. , Gustaw P. , Czarnobilski K. , Sendur R. , Jaworek J. , Yanaihara N.

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nr 1

EN

Tachykinins (TK) are family of peptides including substance P (SP), substance K (SK) and neuromedin K (NK) that have been found in the nerves of the gastrointestinal tract and proposed to act as neurotransmitters to affect the motor, secretory and circulatory functions of the gut, but little is known about their action on the pancreas. In this study three series of tests were carried out to determine the action of SP, SK and NK on pancreatic secretion in conScious dogs and amylase release from the dispersed rat pancreatic acini and to correlate the alterations in pancreatic secretory and circulatory effects of TK in anesthetized dogs. SP, SK and NK infused i. v. in graded doses (0.12-1.0 µg/kg per h) in conscious dogs stimulated pancreatic protein outputs reaching, respectively, 38% and 23% of the maximal response to CCK (40 pmol/kg per h). HCO₃ outputs were also significantly increased but the highest response did not exceed about 5% of secretin (328 pmol/kg per h) maximum. Cholinergic blockade by atropine abolished the pancreatic responses to tachykinins. When added at various concentrations (10⁻¹¹ -10⁻⁷ M) to the incubation medium of rat dispersed pancreatic acini, SK, SP and NK increased in concentration-dependent manner the release of amylase from the resting pancreatic acini and augmented the enzyme release induced by CCK-8 and by urecholine. In anesthetized dogs infused with a background dose of secretin (82 pmol/kg per h), addition of SP, SK and NK caused an immediate and dose-dependent increase in the pancreatic blood flow, oxygen consumption and pancreatic secretion accompanied by a dose-dependent decrease in arterial blood pressure. This study shows that TK are potent pancreatic circulatory stimulants and moderate secretagogues both in vivo and in vitro, acting, at least in part, via cholinergic pathway.

19

Modulation of pancreatic enzyme secretion by melatonin and its precursor; L-tryptophan. Role of CCK and afferent nerves

32%

Leja-Szpak A. , Jaworek J. , Nawrot-Porabka K. , Palonek M. , Mitis-Musiol M. , Dembinski A. , Konturek S. J. , Pawlik W. W.

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nr 2

33-46

EN

Melatonin, a pineal hormone, is also produced in the gastrointestinal tract. Melatonin receptors have been detected in the stomach, intestine and pancreas. This indole inhibits insulin secretion but its role in the physiological modulation of exocrine pancreatic function is yet unknown. The aim of this study was to evaluate the pancreatic secretory effect of melatonin and its precursor; L-tryptophan given intraduodenally (i.d.) to the conscious rats with intact or capsaicin deactivated sensory nerves. CCK1 receptor antagonist; tarazepide, was used in the part of the study to determine the involvement of CCK in the secretory effects of melatonin. The secretory studies were performed on awaken rats surgically equipped with silicone catheters, one of them was inserted into pancreato-biliary duct, the other one - into duodenum. Melatonin (1, 5 or 25 mg/kg) or L-tryptophan (10, 50 or 250 mg/kg) were administered i.d. Samples of pancreatic juice were collected in 15 minutes aliquots. Tarazepide (2,5 mg/kg i.p.) was given to the rats 15 min prior to the administration of melatonin or L-tryptophan. Neurotoxic dose of capsaicin (100 mg/kg s.c.) was used to deactivate afferent nerves and thus to assess the role of these nerves in the melatonin-induced pancreatic enzyme secretion. Administration of melatonin (1, 5 or 25 mg/kg i.d.) or L-tryptophan (10, 50 or 250 mg/kg i.d.) significantly increased pancreatic amylase outputs. Deactivation of sensory nerves by capsaicin or administration of CCK1 - receptor antagonist; tarazepide, reversed the stimulatory effects of melatonin or L-tryptophan on pancreatic secretory function. Administration of melatonin or its amino-acid precursor to the rats resulted in the significant and dose-dependent rises of melatonin and CCK plasma levels. We conclude that melatonin or its precursor; L-tryptophan stimulates pancreatic enzyme secretion via stimulation of CCK release and activation of duodeno-pancreatic reflexes.

20

Effect of neonatal endotoxemia on the pancreas of adult rats

32%

Jaworek J. , Leja-Szpak A. , Nawrot-Porabka K. , Bonior J. , Szklarczyk J. , Kot M. , Konturek S. J. , Tomaszewska R. , Pawlik W. W.

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nr 4

87-102