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1 Acta Neurobiologiae Experimentalis

1 2002

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Proteolysis of endomorphin-1 by brain synaptic membrane-associated peptidases

100%

Wu L. , Chen J. , Zhong D. , Lin C. , Wang X.

Acta Neurobiologiae Experimentalis

2002

tom 62

nr 1

1-5

The biotransformation of endomorphin-1 (EM-1) by brain synaptic membranes has been studied. Peptide fragments of EM-1 that were formed during incubation with membrane preparations in vitro were isolated by High-performance liquid chromatography (HPLC) and characterized using determination of amino acid composition. At pH 7.4, two degradation products, EM-1(1-3) and EM-1(1-2), were identified. EM-1 was degraded 77.5% at 30 min incubation with synaptic membranes. The time course of the experiments and the effect of carboxypeptidase inhibitor (CPI) demonstrated that the proteolysis reaction involves the participation of carboxypeptidase activity.