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Nociceptive dorsal root ganglion neurons

100%

Szulczyk P. , Rola R. , Szulczyk B. , Witkowski G.

Postępy Higieny i Medycyny Doświadczalnej

2002

tom 56

nr 3

361-375

Pain is generated by activation of specific dorsal root ganglion (DRG) neurons termed the nociceptive neurons. The nociceptive DRG neurons express 3 categories of ionic channels a. Channels gated by pain stimuli, b. Channels responsible for the transmission of information from sensory receptors to the spinal cord, c. Channels resposible for the release of neurotransmitters in the spinal cord. There is evidency that kinetic properties, molecular structure and functional significance of the ionic channels expressed in nociceptive DRG neurons are different compared to the other types of DRG neurons. The ionic channels are strictly controlled by receptors for neurotransmitters expressed in the plasma membrane of nociceptive DRG neurons.

Modulation of Ca2+ channel current by mu opioid receptors in prefrontal cortex pyramidal neurons in rats

100%

Rola R. , Jarkiewicz M. , Szulczyk P.

Acta Neurobiologiae Experimentalis

2008

tom 68

nr 1

10-25

Our work assesses the effects of ? opioid receptor activation on high-threshold Ca2+/Ba2+ currents in freshly dispersed pyramidal neurons of the medial prefrontal cortex in rats. Application of the specific ? receptor agonist (D-Ala2, N-Me-Phe4, Gly5-ol)-enkephalin (DAMGO) at 1 muM decreased Ca2+ current amplitudes from 0.72 to 0.49 nA. The effect was abolished by naloxone and ?-Conotoxin GVIA. Inhibition was not abolished by strong depolarisation of the cell membrane. In addition, a macroscopic Ba2+ current recorded in cell-attached configuration was inhibited when DAMGO was applied outside the patch pipette. An adenylyl cyclase inhibitor (SQ 22536) and a protein kinase A inhibitor (H-89) decreased Ca2+ current amplitude. Moreover, the inhibitory effect of mu opioid receptors on Ca2+ currents required the activation of protein kinase A. We conclude that activation of mu opioid receptors in medial prefrontal cortex pyramidal neurons inhibits N type Ca2+ channel currents, and that protein kinase A is involved in this transduction pathway.